While G-protein-coupled receptors (GPCRs) have received considerable attention for their
biological activity in a diversity of physiological functions and have become targets for …

The brain-specific angiogenesis inhibitors 1–3 (BAI1–3) comprise a subfamily of adhesion G-
protein-coupled receptors (GPCRs). These receptors are highly expressed in the brain and …

The insulin receptor-related receptor (IRR), an orphan receptor tyrosine kinase of the insulin
receptor family, can be activated by alkaline media both in vitro and in vivo at pH> 7.9. The …

Latrophilins (LPHN) are part of a yet unexplored family of receptors comprising three
isoforms, LPHN1-3, and belonging to a unique branch of G protein-coupled receptors …

Graphical Abstract Proteolytic processing events in adhesion GPCRs. aGPCRs can undergo
multiple autoproteolytic (red asterisks) and proteolytic processing events by exogenous …

Secretion of mildly alkaline (pH 8.0–8.5) juice to intestines is one of the key functions of the
pancreas. Recent reports indicate that the pancreatic duct system containing the alkaline …

The findings of a recent study associate LPHN3, a member of the latrophilin family, with an
increased risk of developing attention deficit/hyperactivity disorder (ADHD), the most …

IRR is a member of the insulin receptor (IR) family that does not have any known agonist of a
peptide nature but can be activated by mildly alkaline medium and was thus proposed to …

Insulin receptor-related receptor (IRR) is a member of the insulin receptor (IR) family that
works as an extracellular alkali sensor with positive cooperativity. The pH sensing property …

Currently, the molecular mechanisms of the acid-base equilibrium maintenance in the body
remain poorly understood. The development of alkalosis under various pathological …