The discovery of Notch in Drosophila melanogaster nearly a century ago opened the door to
an ever-widening understanding of cellular processes that are controlled or influenced by …

Cancer development results from deregulated control of stem cell populations and
alterations in their surrounding environment. Notch signaling is an important form of direct …

Milk-derived exosomes were identified as a novel mechanism of mother-to-child
transmission of regulatory molecules, but their functions in intestinal tissues of neonates are …

Because Notch signaling is implicated in colon cancer tumorigenesis and protects cells from
apoptosis by inducing prosurvival targets, it was hypothesized that inhibition of Notch …

MicroRNAs (miRNAs) are small non-coding RNAs that regulate the expression of other
genes by transcriptional inhibition or translational repression. miR-34a is a known tumor …

The canonical Notch pathway that has been well characterized over the past 25 years is
relatively simple compared to the plethora of recently published data suggesting non …

Abstract Cyclin‐Dependent Kinase 9 (CDK9) is part of a functional diverse group of
enzymes responsible for cell cycle control and progression. It associates mainly with Cyclin …

The E6 protein of cervical cancer-associated human papillomaviruses (HPVs) is known to
suppress keratinocyte differentiation through unidentified mechanisms. Notch1 is a …

Background Recent studies have implicated aberrant Notch signaling in breast cancers. Yet,
relatively little is known about the pattern of expression of various components of the Notch …

Papillomavirus E6 oncoproteins associate with LXXLL motifs on target cellular proteins to
alter their function. Using a proteomic approach, we found the E6 oncoproteins of cutaneous …