One of the simplest organic functional groups, the alkyne, offers a broad canvas for the
design of cascade transformations in which up to three new bonds can be added to each of …

Differentiating between two highly similar C–H bonds in a given molecule remains a
fundamental challenge in synthetic organic chemistry. Directing group assisted strategies for …

Catalytic site-selective functionalization of distal C–H bonds represents a formidable
challenge in organic synthesis. Particularly, the precise functionalization of distal aromatic C …

Biocatalytic C–H activation has the potential to merge enzymatic and synthetic strategies for
bond formation. FeII/αKG-dependent halogenases are particularly distinguished for their …

Abstract Distal C (sp2)− H and C (sp3)− H functionalizations have recently emerged as step‐
economical tools for molecular synthesis. However, while the C (sp2)− C (sp3) construction …

Ruthenium‐catalyzed σ‐bond activation‐assisted meta‐C− H functionalization has emerged
as a useful tool to forge distal C− C bonds. However, given the limited number of …

The Catellani reaction, ie, the Pd/norbornene (NBE) catalysis, has been evolved into a
versatile approach to multisubstituted arenes via the ortho-functionalization/ipso-termination …

The recently developed palladium-catalyzed C (sp2)–H olefination of 2-arylbenzaldehyde
with the aid of a temporary directing group (TDG) via reversible imine formation delivers …

In 2001, our curiosity to understand the stereochemistry of C− H metalation with Pd
prompted our first studies in Pd (II)‐catalyzed asymmetric C− H activation (RSC Research …

The classic electrophilic bromination leads to ortho-and para-bromination of anilines due to
their electron-rich properties. Herein we report the development of an unprecedented Pd …