Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element
binding proteins (SREBPs). In addition to performing canonical functions in the …

The main biological cause of oxysterols is the oxidation of cholesterol. They differ from
cholesterol by the presence of additional polar groups that are typically hydroxyl, keto …

Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-stimulated gene that shows
broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN …

There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in the
current COVID-19 pandemic and to contain future similar emergencies early on. Specific …

Drug repurposing is potentially the fastest available option in the race to identify safe and
efficacious drugs that can be used to prevent and/or treat COVID‐19. By describing the life …

Oxysterols, the oxidized forms of cholesterol or of its precursors, are formed in the first steps
of cholesterol metabolism. Oxysterols have interested chemists, biologists, and physicians …

With the frequent outbreaks of emerging infectious diseases in recent years, an effective
broad-spectrum antiviral drug is becoming an urgent need for global public health …

Cholesterol is an essential structural component of all membranes of mammalian cells
where it plays a fundamental role not only in cellular architecture, but also, for example, in …

Non‐enzymatic and enzymatic oxidation of lipids has long been a primary issue in human
pathophysiology, with special emphasis on diet‐and nutrition‐related aspects. While there is …

The interferon system protects mammals against virus infections. There are several types of
interferons, which are characterized by their ability to inhibit virus replication and resultant …