Dysregulated cell division, which leads to aberrant cell proliferation, is one of the key
hallmarks of cancer. Therefore, therapeutic targets that block cell division would be effective …

Modern research has revealed that dietary consumption of flavonoids and flavonoids-rich
foods significantly improve cognitive capabilities, inhibit or delay the senescence process …

Alzheimer disease (AD) is the most common form of age-related dementia. The etiology of
AD is considered to be multifactorial as only a negligible percentage of cases have a familial …

Dementia is characterized by the impairment of cognition and behavior of people over 65
years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the …

Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …

The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

Glycogen synthase kinase 3 (GSK-3) is a multifunctional serine/threonine kinase found in all
eukaryotes. The enzyme is a key regulator of numerous signalling pathways, including …

Glycogen synthase kinase-3β (GSK3β) is a fascinating enzyme with an astoundingly diverse
number of actions in intracellular signaling systems. GSK3β activity is regulated by serine …

Identified originally as a regulator of glycogen metabolism, glycogen synthase kinase-3
(GSK3) is now a well-established component of the Wnt signalling pathway, which is …