Copper (Cu) is an essential trace element for all living organisms and used as cofactor in
key enzymes of important biological processes, such as aerobic respiration or superoxide …

Conspectus The human innate immune system has evolved the means to reduce the
bioavailability of first-row late d-block transition metal ions to invading microbial pathogens …

Escherichia coli does not routinely import manganese, but it will do so when iron is
unavailable, so that manganese can substitute for iron as an enzyme cofactor. When …

Copper-binding metallophores, or chalkophores, play a role in microbial copper
homeostasis that is analogous to that of siderophores in iron homeostasis. The best-studied …

Copper avidly binds thiols and is redox active, and it follows that one element of copper
toxicity may be the generation of undesirable disulfide bonds in proteins. In the present …

Tuberculosis is a severe disease affecting millions worldwide. Unfortunately, treatment
strategies are hampered both by the prohibitively long treatment regimen and the rise of …

Copper (Cu) is an essential metal for bacterial physiology but in excess it is bacteriotoxic. To
limit Cu levels in the cytoplasm, most bacteria possess a transcriptionally responsive system …

The metals manganese, iron, cobalt, nickel, copper and zinc are essential for almost all
bacteria, but their precise metal requirements vary by species, by ecological niche and by …

The search for novel bioactive compounds to overcome resistance to current therapeutics
has become of utmost importance. Streptomyces spp. are one of the main sources of …

For bacterial pathogens whose sole environmental reservoir is the human host, the
acquisition of essential nutrients, particularly transition metals, is a critical aspect of survival …