FOXO transcription factor family in cancer and metastasis

Y Jiramongkol, EWF Lam - Cancer and Metastasis Reviews, 2020 - Springer
Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

Forkhead box proteins: tuning forks for transcriptional harmony

EWF Lam, JJ Brosens, AR Gomes, CY Koo - Nature Reviews Cancer, 2013 - nature.com
Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for
fine-tuning the spatial and temporal expression of a broad range of genes both during …

Multiscale embedded gene co-expression network analysis

WM Song, B Zhang - PLoS computational biology, 2015 - journals.plos.org
Gene co-expression network analysis has been shown effective in identifying functional co-
expressed gene modules associated with complex human diseases. However, existing …

Molecular subtyping of triple‐negative breast cancers by immunohistochemistry: molecular basis and clinical relevance

S Zhao, D Ma, Y Xiao, XM Li, JL Ma, H Zhang… - The …, 2020 - academic.oup.com
Background Molecular subtyping of triple‐negative breast cancers (TNBCs) via gene
expression profiling is essential for understanding the molecular essence of this …

Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance

V Adorno-Cruz, G Kibria, X Liu, M Doherty, DJ Junk… - Cancer research, 2015 - AACR
With the goal to remove the roots of cancer, eliminate metastatic seeds, and overcome
therapy resistance, the 2014 inaugural International Cancer Stem Cell (CSC) Conference at …

CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis

J Wu, Z Jiang, C Chen, Q Hu, Z Fu, J Chen, Z Wang… - Cancer letters, 2018 - Elsevier
As a class of endogenous noncoding RNAs, circular RNAs (circRNAs) have been recently
identified to regulate tumourigenesis and progression in multiple malignancies. However …

FOXC1: an emerging marker and therapeutic target for cancer

B Han, N Bhowmick, Y Qu, S Chung, AE Giuliano… - Oncogene, 2017 - nature.com
Abstract The Forkhead box C1 (FOXC1) transcription factor is involved in normal embryonic
development and regulates the development and function of many organs. Most recently, a …

[PDF][PDF] Overexpression of forkhead box C1 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma

L Xia, W Huang, D Tian, H Zhu, X Qi, Z Chen… - …, 2013 - Wiley Online Library
Recurrence and metastasis remain the most common causes of lethal outcomes in
hepatocellular carcinoma (HCC) after curative resection. Thus, it is critical to discover the …

FOXC1 activates smoothened-independent hedgehog signaling in basal-like breast cancer

B Han, Y Qu, Y Jin, Y Yu, N Deng, K Wawrowsky… - Cell reports, 2015 - cell.com
The mesoderm-and epithelial-mesenchymal transition-associated transcription factor
FOXC1 is specifically overexpressed in basal-like breast cancer (BLBC), but its biochemical …

A convex pseudolikelihood framework for high dimensional partial correlation estimation with convergence guarantees

K Khare, SY Oh, B Rajaratnam - Journal of the Royal Statistical …, 2015 - academic.oup.com
Sparse high dimensional graphical model selection is a topic of much interest in modern day
statistics. A popular approach is to apply l 1-penalties to either parametric likelihoods, or …