The intricate patterning processes that establish the complex vascular system during
development depend on a combination of intrinsic pre-patterning and extrinsic responses to …

The notochord is the defining structure of the chordates, and has essential roles in
vertebrate development. It serves as a source of midline signals that pattern surrounding …

Context.—Chordomas are uncommon malignant neoplasms with notochordal differentiation
encountered by neuropathologists, bone/soft tissue pathologists, and general surgical …

The location and movement of mammalian gut tissue progenitors, prior to the expression of
tissue-specific genes, has been unknown, but this knowledge is essential to identify …

An understanding of developmental biology can provide useful insights into how different
tissue-engineered repairs might be designed. During embryogenesis of the intervertebral …

The endoderm gives rise to the lining of the esophagus, stomach and intestines, as well as
associated organs. To generate a functional intestine, a series of highly orchestrated …

Identifying the genes that underlie the pathogenesis of chromosome deletion and
duplication syndromes is a challenge because the affected chromosomal segment can …

Basement membranes are thought to be essential for organ formation, providing the scaffold
on which individual cells organize to form complex tissues. Laminins are integral …

The notochord is an embryonic midline structure common to all members of the phylum
Chordata, providing both mechanical and signaling cues to the developing embryo. In …

In today's world there is an ever increasing incidence of low back pain, which is generally
attributed to degeneration of the intervertebral disc (IVD) in those in their second or third …