Advances and challenges in gene‐based approaches for osteoarthritis

H Madry, M Cucchiarini - The journal of gene medicine, 2013 - Wiley Online Library
Osteoarthritis (OA), a paramount cause of physical disability for which there is no definitive
cure, is mainly characterized by the gradual loss of the articular cartilage. Current …

Articular cartilage degradation and aberrant subchondral bone remodeling in patients with osteoarthritis and osteoporosis

L Chu, X Liu, Z He, X Han, M Yan, X Qu… - Journal of Bone and …, 2020 - academic.oup.com
Osteoarthritis (OA) and osteoporosis (OP) are two skeletal disorders associated with joint
structures. Occasionally, OA and OP occur in the same patient. However, the effect of OP …

Inflammatory factors are crucial for the pathogenesis of post-traumatic osteoarthritis confirmed by a novel porcine model:“Idealized” anterior cruciate ligament …

R Zhao, Z Dong, X Wei, X Gu, P Han, H Wu… - International …, 2021 - Elsevier
Objective To determine whether idealized anterior cruciate ligament reconstruction (IACL-R)
restores normal gait features, and whether inflammatory factors are involved in the …

[HTML][HTML] Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone

MR McCann, C Yeung, MA Pest, A Ratneswaran… - Osteoarthritis and …, 2017 - Elsevier
Objective Low-amplitude, high-frequency whole-body vibration (WBV) has been adopted for
the treatment of musculoskeletal diseases including osteoarthritis (OA); however, there is …

Pharmacologically-induced stress has minimal impact on judgement and attention biases in sheep

JE Monk, S Belson, C Lee - Scientific Reports, 2019 - nature.com
The emotional impact of exposure to stressors has not been well quantified in animals. We
hypothesised that exogenous induction of stress in sheep would induce a pessimistic …

Effects of alendronate on cartilage lesions and micro-architecture deterioration of subchondral bone in patellofemoral osteoarthritic ovariectomized rats with patella …

M Bei, Z Zheng, Y Xiao, N Liu, X Cao, F Tian… - Journal of Orthopaedic …, 2024 - Springer
Background Patellofemoral osteoarthritis (PFJOA) is a subtype of knee OA, which is one of
the main causes of anterior knee pain. The current study found an increased prevalence of …

[HTML][HTML] Evaluating pharmacological models of high and low anxiety in sheep

RE Doyle, C Lee, DM McGill, M Mendl - PeerJ, 2015 - peerj.com
New tests of animal affect and welfare require validation in subjects experiencing putatively
different states. Pharmacological manipulations of affective state are advantageous because …

Comparison between invasive blood pressure and a non-invasive blood pressure monitor in anesthetized sheep

D Almeida, M Barletta, L Mathews, L Graham… - Research in veterinary …, 2014 - Elsevier
Monitoring blood pressure under general anesthesia in animals is important to prevent
hypotension and poor tissue perfusion. Thirteen sheep were enrolled to evaluate the …

A new anchor augmentation technique with a cancellous screw in osteoporotic rotator cuff repair: an in vitro biomechanical study on sheep humerus specimens

V Uruc, R Ozden, Y Dogramacı, A Kalacı… - … : The Journal of …, 2014 - Elsevier
Purpose The aim of this study was to test a simple technique to augment the pullout
resistance of an anchor in an over-drilled sheep humerus model. Methods Sixty-four paired …

Establishment of a rat model for osteoarthritis resulting from anterior cruciate ligament rupture and its significance

X Ouyang, J Wang, SD Hong, F Xin… - Experimental and …, 2015 - spandidos-publications.com
The purpose of this study was to examine the establishment of a model concerned with
osteoarthritis resulting from the anterior cruciate ligament rupture of rats and investigate the …