Roles and functions of HIV-1 Tat protein in the CNS: an overview
A Bagashev, BE Sawaya - Virology journal, 2013 - Springer
Nearly 50% of HIV-infected individuals suffer from some form of HIV-associated
neurocognitive disorders (HAND). HIV-1 Tat (a key HIV t rans a ctivator of t ranscription) …
neurocognitive disorders (HAND). HIV-1 Tat (a key HIV t rans a ctivator of t ranscription) …
Overview of the structure and function of the dopamine transporter and its protein interactions
The dopamine transporter (DAT) plays an integral role in dopamine neurotransmission
through the clearance of dopamine from the extracellular space. Dysregulation of DAT is …
through the clearance of dopamine from the extracellular space. Dysregulation of DAT is …
Cross-talk between microglia and neurons regulates HIV latency
D Alvarez-Carbonell, F Ye, N Ramanath… - PLoS …, 2019 - journals.plos.org
Despite effective antiretroviral therapy (ART), HIV-associated neurocognitive disorders
(HAND) are found in nearly one-third of patients. Using a cellular co-culture system …
(HAND) are found in nearly one-third of patients. Using a cellular co-culture system …
HIV, Tat and dopamine transmission
Abstract Human Immunodeficiency Virus (HIV) is a progressive infection that targets the
immune system, affecting more than 37 million people around the world. While …
immune system, affecting more than 37 million people around the world. While …
Selective vulnerability of striatal D2 versus D1 dopamine receptor-expressing medium spiny neurons in HIV-1 Tat transgenic male mice
Despite marked regional differences in HIV susceptibility within the CNS, there has been
surprisingly little exploration into the differential vulnerability among neuron types and the …
surprisingly little exploration into the differential vulnerability among neuron types and the …
Opioid and neuroHIV comorbidity–current and future perspectives
With the current national opioid crisis, it is critical to examine the mechanisms underlying
pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in …
pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in …
Role of macrophage dopamine receptors in mediating cytokine production: implications for neuroinflammation in the context of HIV-associated neurocognitive …
Despite the success of combination anti-retroviral therapy (cART), around 50% of HIV-
infected individuals still display a variety of neuropathological and neurocognitive sequelae …
infected individuals still display a variety of neuropathological and neurocognitive sequelae …
Molecular mechanisms involved in HIV-1 Tat-mediated induction of IL-6 and IL-8 in astrocytes
AR Nookala, A Kumar - Journal of neuroinflammation, 2014 - Springer
Background HIV-associated neurocognitive disorders (HAND) exist in approximately 50% of
infected individuals even after the introduction of highly active antiretroviral therapy. HIV-1 …
infected individuals even after the introduction of highly active antiretroviral therapy. HIV-1 …
The role of HIV infection in neurologic injury
The central nervous system (CNS) is a very challenging HIV-1 sanctuary, in which HIV-1
replication is established early on during acute infection and can persist despite potent …
replication is established early on during acute infection and can persist despite potent …
HIV-1 TAT protein enhances sensitization to methamphetamine by affecting dopaminergic function
Methamphetamine abuse is common among humans with immunodeficiency virus (HIV).
The HIV-1 regulatory protein TAT induces dysfunction of mesolimbic dopaminergic systems …
The HIV-1 regulatory protein TAT induces dysfunction of mesolimbic dopaminergic systems …