It is estimated that over 10% of the adult population in developed countries have some
degree of chronic kidney disease (CKD). CKD is a progressive and irreversible deterioration …

Background Diabetic kidney disease (DKD) is one of the major chronic microvascular
complications in diabetes mellitus, and may progress to end‐stage kidney disease (ESKD) …

Berberine (BBR) was previously found to have beneficial effects on renal injury in
experimental diabetic rats. However, the mechanisms underlying the effects are not fully …

The present study was conducted to determine whether and how store-operated Ca2+ entry
(SOCE) in glomerular mesangial cells (MCs) was altered by high glucose (HG) and …

Accumulation of extracellular matrix derived from glomerular mesangial cells is an early
feature of diabetic nephropathy. Ca 2+ signals mediated by store–operated Ca 2+ channels …

Diabetic kidney disease (DKD) is a devastating kidney disease and lacks effective
therapeutic interventions. The present study was aimed to determine whether reconstituted …

This study was carried out to explore the molecular mechanism for down-regulation of
TRPC6 expression in the reactive oxygen species (ROS)/PKC signaling in kidney cells. In …

Positioned at the head of the nephron, the renal corpuscle generates a plasma ultrafiltrate to
initiate urine formation. Three major cell types within the renal corpuscle, the glomerular …

目的利用2 型糖尿病不同病程人群空腹及葡萄糖口服应激模型, 研究葡萄糖应激对人体自由基
代谢指标变化的影响, 探讨血糖波动与氧化应激水平和机体抗氧化代偿能力的关系 …

Store-operated Ca2+ entry (SOCE) is mediated by the store-operated Ca2+ channel (SOC)
that opens upon depletion of internal Ca2+ stores following activation of G protein-coupled …