Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and
represents one of the earliest pathomechanistic alterations throughout the AD continuum …

Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …

Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …

Background Increasingly, evidence from brain imaging supports the role of
neuroinflammation in dementia progression. Yet, it is not clear if there are patterns of spatial …

The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …

Tauopathies are classified according to whether tau deposits predominantly contain tau
isoforms with three or four repeats of the microtubule-binding domain. Those in which four …

Alzheimer's disease (AD) is a devastating and progressive neurodegenerative disease for
which there is no cure. Mild cognitive impairment (MCI) is considered a prodromal stage of …

Parkinson's disease (PD) and atypical Parkinsonian syndromes are progressive
heterogeneous neurodegenerative diseases that share clinical characteristic of …

Neuroinflammation is a key part of the etio-pathogenesis of Alzheimer's disease (AD). We
tested the relationship between neuroinflammation and the disruption of functional …