Neurofibromin is a large and multifunctional protein encoded by the tumor suppressor gene
NF1, mutations of which cause the tumor predisposition syndrome neurofibromatosis type 1 …

The RASopathies are a clinically defined group of medical genetic syndromes caused by
germline mutations in genes that encode components or regulators of the Ras/mitogen …

Somatic, gain-of-function mutations in ras genes were the first specific genetic alterations
identified in human cancer about 3 decades ago. Studies during the last quarter century …

The Ras/mitogen activated protein kinase (MAPK) pathway is essential in the regulation of
the cell cycle, differentiation, growth and cell senescence, all of which are critical to normal …

Three new neurofibromatosis type 1 (NFl) mutations have been detected and characterized.
Pulsed-field gel and Southern blot analyses reveal the mutations lo be deletions of 190, 40 …

Overlapping cDNA clones from the translocation breakpoint region (TBR) gene, recently
discovered at the neurofibromatosis type 1 locus and found to be interrupted by deletions …

The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

Summary Historically, neurofibromatosis 1 (NF1) has been inextricably linked with
neurofibromatosis 2 (NF2). Both are inherited autosomal-dominant neurocutaneous …

Neurofibromatosis type 1 (NF1), also called von Recklinghausen disease or peripheral
neurofibromatosis, is a common autosomal dominant disorder characterised by multiple …

The initial adhesive interactions between circulating leukocytes and endothelia are
mediated, in part, by P-selectin. We now report the expression cloning of a functional iigand …