Background The protein p53, encoded by the most frequently mutated gene TP53 in human
cancers, has diverse functions in tumor suppression. As a best known transcription factor …

Simple Summary Post-translational modifications (PTMs) strongly influence the stability and
function of proteins. These modifications have been reported to affect wild-type (wt) p53 as …

The commitment of stem cells to differentiate into osteoblasts is a highly regulated and
complex process that involves the coordination of extrinsic signals and intrinsic …

REarranged during Transfection (RET) oncogenic rearrangements can occur in 1–2% of
lung adenocarcinomas. While RET-driven NSCLC models have been developed using …

Cancer research remains clinically unmet in many areas due to limited access to patient
samples and the lack of reliable model systems that truly reflect human cancer biology. The …

Inflammasomes are cytosolic multi-protein complexes that play an important role in the
innate immune system, inducing cytokine maturation and pyroptosis. Trained immunity is the …

Background Neuropathic pain (NP) is a kind of intractable pain. The pathogenesis of NP
remains a complicated issue for pain management practitioners. SPARC/osteonectin …

The N6‑methyladenosine reader YTH N6‑methyladenosine RNA binding protein 1
(YTHDF1) has been assessed in several tumor types and holds significance in the tumor …

The p53 tumor suppressor gene governs a multitude of complex cellular processes that are
essential for anti-cancer function and whose dysregulation leads to aberrant gene …

Although amplification/overexpression is the predominant mechanism for the oncogenic
properties of MDM2, an increasing number of MDM2 somatic missense mutations were …