DNA methylation in mammalian development and disease
ZD Smith, S Hetzel, A Meissner - Nature Reviews Genetics, 2024 - nature.com
The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …
characterization to one seeking deeper functional understanding of how this modification …
The placenta: epigenetic insights into trophoblast developmental models of a generation-bridging organ with long-lasting impact on lifelong health
M Hemberger, W Dean - Physiological Reviews, 2023 - journals.physiology.org
The placenta is a unique organ system that functionally combines both maternal and fetal
cell types with distinct lineage origins. Normal placentation is critical for developmental …
cell types with distinct lineage origins. Normal placentation is critical for developmental …
Multiplexed chromatin immunoprecipitation sequencing for quantitative study of histone modifications and chromatin factors
ChIP–seq is a widely used technique for studying histone post-translational modifications
and DNA-binding proteins. DNA fragments associated with a specific protein or histone …
and DNA-binding proteins. DNA fragments associated with a specific protein or histone …
DeepBAM: a high-accuracy single-molecule CpG methylation detection tool for Oxford nanopore sequencing
X Bai, HC Yao, B Wu, LR Liu, YY Ding… - Briefings in …, 2024 - academic.oup.com
Recent nanopore sequencing system (R10. 4) has enhanced base calling accuracy and is
being increasingly utilized for detecting CpG methylation state. However, the robustness and …
being increasingly utilized for detecting CpG methylation state. However, the robustness and …
Conserved and divergent features of trophoblast stem cells
Trophoblast stem cells (TSCs) are a proliferative multipotent population derived from the
trophectoderm of the blastocyst, which will give rise to all the functional cell types of the …
trophectoderm of the blastocyst, which will give rise to all the functional cell types of the …
Stem cell transcriptional profiles from mouse subspecies reveal cis-regulatory evolution at translation genes
NM Simon, Y Kim, DM Bautista, JR Dutton, RB Brem - Heredity, 2024 - nature.com
A key goal of evolutionary genomics is to harness molecular data to draw inferences about
selective forces that have acted on genomes. The field progresses in large part through the …
selective forces that have acted on genomes. The field progresses in large part through the …
Spatiotemporal DNA methylation dynamics shape megabase-scale methylome landscapes
H Toh, H Sasaki - Life Science Alliance, 2024 - life-science-alliance.org
DNA methylation is an essential epigenetic mechanism that regulates cellular
reprogramming and development. Studies using whole-genome bisulfite sequencing have …
reprogramming and development. Studies using whole-genome bisulfite sequencing have …
Collective Processes In Cellular Reprogramming
A Mohammadzadehhashtroud - 2024 - tud.qucosa.de
Abstract (EN) Epigenetics comprises chemical modifications of the DNA and the proteins
that the DNA is wrapped around them. These modifications play key roles in establishing …
that the DNA is wrapped around them. These modifications play key roles in establishing …