The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory
factor (TRF) that controls many distinct gene networks, each uniquely determined by …

Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and
physiological function of virtually all tissues. TH binds to receptors that are ligand …

Ligand-dependent activation of transcription by nuclear receptors (NRs) is mediated by
interactions with coactivators. Receptor agonists promote coactivator binding, and …

The state of chromatin (the packaging of DNA in eukaryotes) has long been recognized to
have major effects on levels of gene expression, and numerous chromatin-altering …

The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-dependent
transcription factor that is important in adipocyte differentiation and glucose homeostasis …

The nuclear hormone receptor superfamily includes receptors for thyroid and steroid
hormones, retinoids and vitamin D, as well as different “orphan” receptors of unknown …

Nuclear receptors (NR) comprise a family of transcription factors that regulate gene
expression in a liganddependent manner. Members of the NR superfamily include receptors …

NUCLEAR receptor coregulators are coactivators or corepressors that are required by
nuclear receptors for efficient transcriptional regulation. In this context, we define …

The p160 family of coactivators, SRC-1, GRIP1/TIF2, and p/CIP, mediate transcriptional
activation by nuclear hormone receptors. Coactivator-associated arginine methyltransferase …

The biological action of androgens is mediated through the androgen receptor (AR).
Androgen-bound AR functions as a transcription factor to regulate genes involved in an …