TAR DNA binding protein 43 (TDP-43) is a DNA/RNA binding protein involved in pivotal
cellular functions, especially in RNA metabolism. Hyperphosphorylated and ubiquitinated …

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are
neurodegenerative disorders that exist on a disease spectrum due to pathological, clinical …

The discovery that prion protein can misfold into a pathological conformation that encodes
structural information capable of both propagation and inducing severe neuropathology has …

FUS and TDP-43, two RNA-binding proteins from the heterogeneous nuclear
ribonucleoprotein family, have gained significant attention in the field of neurodegenerative …

Cortical hyperexcitability and mislocalization of the RNA-binding protein TDP43 are highly
conserved features in amyotrophic lateral sclerosis (ALS). Nevertheless, the relationship …

Biomolecular condensates, which assemble via the process of liquid–liquid phase
separation (LLPS), are multicomponent compartments found ubiquitously inside cells …

Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the
exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely …

ATP is the universal energy currency for all cells but has cellular concentrations of 2–12 mM,
much higher than required for its classic functions. RNA-recognition motif (RRM) constitutes …

The argasid tick Ornithodoros moubata is the main vector of human relapsing fever (HRF)
and African swine fever (ASF) in Africa. Salivary proteins are part of the host-tick interface …

Abstract Background The argasid tick Ornithodoros erraticus is the main vector of tick-borne
human relapsing fever (TBRF) and African swine fever (ASF) in the Mediterranean Basin …