Mass spectrometry imaging and integration with other imaging modalities for greater molecular understanding of biological tissues

T Porta Siegel, G Hamm, J Bunch, J Cappell… - Molecular imaging and …, 2018 - Springer
Over the last two decades, mass spectrometry imaging (MSI) has been increasingly
employed to investigate the spatial distribution of a wide variety of molecules in complex …

Multimodal imaging mass spectrometry: next generation molecular mapping in biology and medicine

EK Neumann, KV Djambazova… - Journal of the …, 2020 - ACS Publications
Imaging mass spectrometry has become a mature molecular mapping technology that is
used for molecular discovery in many medical and biological systems. While powerful by …

[HTML][HTML] Metabolic fingerprinting links oncogenic PIK3CA with enhanced arachidonic acid-derived eicosanoids

N Koundouros, E Karali, A Tripp, A Valle, P Inglese… - Cell, 2020 - cell.com
Oncogenic transformation is associated with profound changes in cellular metabolism, but
whether tracking these can improve disease stratification or influence therapy decision …

The surgical intelligent knife distinguishes normal, borderline and malignant gynaecological tissues using rapid evaporative ionisation mass spectrometry (REIMS)

DL Phelps, J Balog, LF Gildea, Z Bodai… - British journal of …, 2018 - nature.com
Background Survival from ovarian cancer (OC) is improved with surgery, but surgery can be
complex and tumour identification, especially for borderline ovarian tumours (BOT), is …

Metabolomics technology and bioinformatics for precision medicine

RK Azad, V Shulaev - Briefings in bioinformatics, 2019 - academic.oup.com
Precision medicine is rapidly emerging as a strategy to tailor medical treatment to a small
group or even individual patients based on their genetics, environment and lifestyle …

Mass spectrometry-based proteomics as an emerging tool in clinical laboratories

AG Birhanu - Clinical Proteomics, 2023 - Springer
Mass spectrometry (MS)-based proteomics have been increasingly implemented in various
disciplines of laboratory medicine to identify and quantify biomolecules in a variety of …

Miniature mass spectrometers and their potential for clinical point‐of‐care analysis

Y Zhai, X Fu, W Xu - Mass Spectrometry Reviews, 2024 - Wiley Online Library
Mass spectrometry (MS) has become a powerful technique for clinical applications with high
sensitivity and specificity. Different from conventional MS diagnosis in laboratory, point‐of …

The intelligent knife (iKnife) and its intraoperative diagnostic advantage for the treatment of cervical disease

M Tzafetas, A Mitra, M Paraskevaidi… - Proceedings of the …, 2020 - National Acad Sciences
Clearance of surgical margins in cervical cancer prevents the need for adjuvant
chemoradiation and allows fertility preservation. In this study, we determined the capacity of …

Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI) in Disease Diagnosis: An Overview.

BS Kumar - Analytical Methods, 2023 - pubs.rsc.org
Tissue analysis, which is essential to histology and is considered the benchmark for the
diagnosis and prognosis of many illnesses, including cancer, is significant. During surgery …

Intra-operative spectroscopic assessment of surgical margins during breast conserving surgery

DW Shipp, EA Rakha, AA Koloydenko… - Breast Cancer …, 2018 - Springer
Background In over 20% of breast conserving operations, postoperative pathological
assessment of the excised tissue reveals positive margins, requiring additional surgery …