Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …
[HTML][HTML] Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants
The BQ and XBB subvariants of SARS-CoV-2 Omicron are now rapidly expanding, possibly
due to altered antibody evasion properties deriving from their additional spike mutations …
due to altered antibody evasion properties deriving from their additional spike mutations …
Heterogenous humoral and cellular immune responses with distinct trajectories post-SARS-CoV-2 infection in a population-based cohort
To better understand the development of SARS-CoV-2-specific immunity over time, a
detailed evaluation of humoral and cellular responses is required. Here, we characterize …
detailed evaluation of humoral and cellular responses is required. Here, we characterize …
[HTML][HTML] Evolving antibody evasion and receptor affinity of the Omicron BA. 2.75 sublineage of SARS-CoV-2
Summary SARS-CoV-2 Omicron BA. 2.75 has diversified into multiple subvariants with
additional spike mutations and several are expanding in prevalence, particularly CH. 1.1 …
additional spike mutations and several are expanding in prevalence, particularly CH. 1.1 …
[HTML][HTML] Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa
A Simonis, C Kreer, A Albus, K Rox, B Yuan… - Cell, 2023 - cell.com
Drug-resistant Pseudomonas aeruginosa (PA) poses an emerging threat to human health
with urgent need for alternative therapeutic approaches. Here, we deciphered the B cell and …
with urgent need for alternative therapeutic approaches. Here, we deciphered the B cell and …
Growth, molecular docking, Hirshfeld surface analysis and first-principles investigation on the structural, morphological and mechanical properties of the OIH hybrid …
Single crystals of the dithiobis-(formamidinium) bis-(hydrogen sulfate) C 2 H 8 N 4 S 2 2+·
2HSO 4− hybrid compound was growth by slow evaporation method at room temperature …
2HSO 4− hybrid compound was growth by slow evaporation method at room temperature …
Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential
There has been limited characterisation of bat-borne coronaviruses in Europe. Here, we
screened for coronaviruses in 48 faecal samples from 16 of the 17 bat species breeding in …
screened for coronaviruses in 48 faecal samples from 16 of the 17 bat species breeding in …
Potent antibodies against immune invasive SARS-CoV-2 Omicron subvariants
L Wang, Y Wang, H Zhou - International Journal of Biological …, 2023 - Elsevier
The development of neutralizing antibodies (nAbs) is an important strategy to tackle the
Omicron variant. Omicron N-terminal domain (NTD) mutations including A67V, G142D, and …
Omicron variant. Omicron N-terminal domain (NTD) mutations including A67V, G142D, and …
Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host …
Investigation of potential hosts of the severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) is crucial to understanding future risks of spillover and spillback. SARS-CoV …
(SARS-CoV-2) is crucial to understanding future risks of spillover and spillback. SARS-CoV …