Polyoxometalates (POMs) are discrete polynuclear metal-oxo anions with a fascinating
variety of structures and unique chemical and physical properties. Their application in …

NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen
species-generating enzymes that broadly and specifically regulate redox-sensitive …

Abscisic acid (ABA) is a ubiquitous hormone that regulates plant growth, development and
responses to environmental stresses. Its action is mediated by the PYR/PYL/RCAR family of …

Protein tyrosine phosphatases (PTPs) play a critical role in regulating cellular functions by
selectively dephosphorylating their substrates. Here we present 22 human PTP crystal …

The dual-specificity phosphatase 6 (Dusp6) functions as a feedback regulator of fibroblast
growth factor (FGF) signaling to limit the activity of extracellular signal–regulated kinases …

Protein phosphorylation is one of the most widely observed and important post-translational
modification (PTM) processes. Protein phosphorylation is regulated by protein kinases, each …

Phosphatases of the haloacid dehalogenase (HAD) superfamily of hydrolases are an
ancient and very large class of enzymes that have evolved to dephosphorylate a wide range …

Over the past two decades increasing information about the function and structural detail of
phosphatases has become available detailing the interaction with vanadate or other …

Protein tyrosine phosphatases (PTPs) are important targets of the H2O2 that is produced
during mammalian signal transduction. H2O2-mediated inactivation of PTPs also may be …

Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation
of biological processes. Compound toxicities, chemical alterations by metabolism …