All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms
develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Extracellular biophysical properties have particular implications for a wide spectrum of
cellular behaviors and functions, including growth, motility, differentiation, apoptosis, gene …

Myocardial fibroblasts play a crucial role in heart structure and function. In recent years,
significant progress has been made in understanding the epigenetic regulation of …

Epigenetic marks regulate the transcriptomic landscape by facilitating the structural packing
and unwinding of the genome, which is tightly folded inside the nucleus. Lysine-specific …

The nucleosome is a DNA–protein assembly that is the basic unit of chromatin. A
nucleosome can adopt various structures. In the canonical nucleosome structure, 145–147 …

Genetic information in eukaryotic organisms is stored, replicated, transcribed, and inherited
through the nucleus of a cell. Epigenetic modifications in the genetic material, including DNA …

Recent development of genome editing (GE) tools has revolutionized crop improvement due
to their ability to perform targeted genetic modifications. Among different generations of GE …

Epigenetic regulation, which is characterized by reversible and heritable genetic alterations
without changing DNA sequences, has recently been increasingly studied in diseases …

The mechanical environment plays an important role in influencing cell identity. The
nucleus's organization and mechanical state are essential regulators of cellular function …