Nitric oxide (NO) is involved in many physiological processes and several lines of evidence
have indicated that NO plays a complex and diverse role in the modulation of pain. Nitric …

Exercise-induced analgesia is a phenomenon discussed worldwide. This effect began to be
investigated in the early 1970s in healthy individuals and rodents during and after an acute …

Beneficial physiological effects of long-chain n-3 polyunsaturated fatty acids are widely
accepted but the mechanism (s) by which these fatty acids act remains unclear. Herein, we …

Epoxygenated fatty acids (EpFAs), which are lipid mediators produced by cytochrome P450
epoxygenases from polyunsaturated fatty acids, are important signaling molecules known to …

Objective The purpose of this study was to examine the interaction between the endogenous
opioid and endocannabinoid (eCB) systems in a pain modulatory process known as …

This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …

It is generally believed that NMDA receptor antagonism accounts for most of the anesthetic
and analgesic effects of ketamine, however, it interacts at multiple sites in the central …

While effective in treating abdominal pain, opioids have significant side effects. Recent
legalization of cannabis will likely promote use of cannabinoids as an adjunct or alternative …

Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced
bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced …

BACKGROUND: Cannabinoid agonists induce norepinephrine release in central, spinal,
and peripheral sites. Previous studies suggest an interaction between the cannabinoid and …