What do drug transporters really do?
SK Nigam - Nature reviews Drug discovery, 2015 - nature.com
Potential drug–drug interactions mediated by the ATP-binding cassette (ABC) transporter
and solute carrier (SLC) transporter families are of clinical and regulatory concern. However …
and solute carrier (SLC) transporter families are of clinical and regulatory concern. However …
The organic anion transporter (OAT) family: a systems biology perspective
The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22
(solute carrier 22) transporter family, has received a great deal of attention because of its …
(solute carrier 22) transporter family, has received a great deal of attention because of its …
Handling of drugs, metabolites, and uremic toxins by kidney proximal tubule drug transporters
The proximal tubule of the kidney plays a crucial role in the renal handling of drugs (eg,
diuretics), uremic toxins (eg, indoxyl sulfate), environmental toxins (eg, mercury, aristolochic …
diuretics), uremic toxins (eg, indoxyl sulfate), environmental toxins (eg, mercury, aristolochic …
The SLC22 transporter family: a paradigm for the impact of drug transporters on metabolic pathways, signaling, and disease
SK Nigam - Annual review of pharmacology and toxicology, 2018 - annualreviews.org
The SLC22 transporter family consists of more than two dozen members, which are
expressed in the kidney, the liver, and other tissues. Evolutionary analysis indicates that …
expressed in the kidney, the liver, and other tissues. Evolutionary analysis indicates that …
Drug transporters in drug efficacy and toxicity
MK DeGorter, CQ Xia, JJ Yang… - Annual review of …, 2012 - annualreviews.org
Drug transporters are now widely acknowledged as important determinants governing drug
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion
One approach to experimental science involves creating hypotheses, then testing them by
varying one or more independent variables, and assessing the effects of this variation on the …
varying one or more independent variables, and assessing the effects of this variation on the …
Renal organic anion transporters (SLC22 family): expression, regulation, roles in toxicity, and impact on injury and disease
Organic solute flux across the basolateral and apical membranes of renal proximal tubule
cells is a key process for maintaining systemic homeostasis. It represents an important route …
cells is a key process for maintaining systemic homeostasis. It represents an important route …
The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so
A recent paper in this journal sought to counter evidence for the role of transport proteins in
effecting drug uptake into cells, and questions that transporters can recognize drug …
effecting drug uptake into cells, and questions that transporters can recognize drug …
[HTML][HTML] Diuretic resistance in patients with kidney disease: Challenges and opportunities
L Guo, B Fu, Y Liu, N Hao, Y Ji, H Yang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Edema caused by kidney disease is called renal edema. Edema is a common symptom of
many human kidney diseases. Patients with renal edema often need to take diuretics …
many human kidney diseases. Patients with renal edema often need to take diuretics …
Recent advance in the pharmacogenomics of human Solute Carrier Transporters (SLCs) in drug disposition
Drug pharmacokinetics is influenced by the function of metabolising enzymes and
influx/efflux transporters. Genetic variability of these genes is known to impact on clinical …
influx/efflux transporters. Genetic variability of these genes is known to impact on clinical …