Molnupiravir: A new candidate for COVID‐19 treatment

F Pourkarim, S Pourtaghi‐Anvarian… - Pharmacology …, 2022 - Wiley Online Library
The novel coronavirus disease 2019 (COVID‐19) emerged in late December 2019 in china
and has rapidly spread to many countries around the world. The effective pharmacotherapy …

Molnupiravir and its antiviral activity against COVID-19

L Tian, Z Pang, M Li, F Lou, X An, S Zhu… - Frontiers in …, 2022 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) constitutes a major worldwide public health threat …

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label …

CC Butler, FDR Hobbs, OA Gbinigie, NM Rahman… - The Lancet, 2023 - thelancet.com
Background The safety, effectiveness, and cost-effectiveness of molnupiravir, an oral
antiviral medication for SARS-CoV-2, has not been established in vaccinated patients in the …

[PDF][PDF] Therapeutics and COVID-19: living guideline, 14 July 2022

World Health Organization - 2022 - apps.who.int
As of May 2022, there have been over 524 million confirmed cases of COVID-19 (10). The
pandemic has thus far claimed approximately 6.2 million lives (10). Vaccination is having a …

A living WHO guideline on drugs for covid-19

A Agarwal, BJ Hunt, M Stegemann, B Rochwerg… - bmj, 2020 - bmj.com
Updates This is the fourteenth version (thirteenth update) of the living guideline, replacing
earlier versions (available as data supplements). New recommendations will be published …

[PDF][PDF] A living WHO guideline on drugs for covid-19

F Lamontagne, T Agoritsas, H Macdonald, YS Leo… - bmj, 2020 - zyicu.cn
The evidence base for therapeutics for covid-19 is evolving with numerous randomised
controlled trials (RCTs) recently completed and under way. This update adds new …

The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern

R Abdelnabi, CS Foo, D Jochmans, L Vangeel… - Nature …, 2022 - nature.com
There is an urgent need for potent and selective antivirals against SARS-CoV-2. Pfizer
developed PF-07321332 (PF-332), a potent inhibitor of the viral main protease (Mpro …

Molnupiravir inhibits replication of the emerging SARS-CoV-2 variants of concern in a hamster infection model

R Abdelnabi, CS Foo, S De Jonghe… - The Journal of …, 2021 - academic.oup.com
The emergence of SARS-CoV-2 variants of concern (VoCs) has exacerbated the COVID-19
pandemic. Currently available monoclonal antibodies and vaccines appear to have reduced …

[HTML][HTML] Combination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected mice

JH Jeong, S Chokkakula, SC Min, BK Kim, WS Choi… - Antiviral research, 2022 - Elsevier
As the SARS-CoV-2 pandemic remains uncontrolled owing to the continuous emergence of
variants of concern, there is an immediate need to implement the most effective antiviral …

Molnupiravir: A lethal mutagenic drug against rapidly mutating severe acute respiratory syndrome coronavirus 2—A narrative review

S Masyeni, M Iqhrammullah… - Journal of Medical …, 2022 - Wiley Online Library
Broad‐spectrum antiviral agents targeting viral RNA‐dependent RNA polymerase (RdRp)
are expected to be a key therapeutic strategy in the ongoing coronavirus disease 2019 …