PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis
SM Schultze, BA Hemmings, M Niessen… - Expert reviews in …, 2012 - cambridge.org
New therapeutic approaches to counter the increasing prevalence of obesity and type 2
diabetes mellitus are in high demand. Deregulation of the phosphoinositide-3-kinase …
diabetes mellitus are in high demand. Deregulation of the phosphoinositide-3-kinase …
AICAr, a widely used AMPK activator with important AMPK-independent effects: a systematic review
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most
commonly used pharmacological modulators of AMPK activity. The majority of early studies …
commonly used pharmacological modulators of AMPK activity. The majority of early studies …
AMPK directly activates mTORC2 to promote cell survival during acute energetic stress
AMP-activated protein kinase (AMPK) senses energetic stress and, in turn, promotes
catabolic and suppresses anabolic metabolism coordinately to restore energy balance. We …
catabolic and suppresses anabolic metabolism coordinately to restore energy balance. We …
[HTML][HTML] Targeting AMPK for cancer prevention and treatment
AMP-activated protein kinase (AMPK) is an important mediator in maintaining cellular
energy homeostasis. AMPK is activated in response to a shortage of energy. Once activated …
energy homeostasis. AMPK is activated in response to a shortage of energy. Once activated …
Targeting PI3K/AKT/mTOR network for treatment of leukemia
J Bertacchini, N Heidari, L Mediani, S Capitani… - Cellular and molecular …, 2015 - Springer
Objective Increased activity of PI3K/AKT/mTOR pathway has been observed in a huge
number of malignancies. This pathway can function as a prosurvival factor in leukemia stem …
number of malignancies. This pathway can function as a prosurvival factor in leukemia stem …
BH3-only proteins Noxa and Puma are key regulators of induced apoptosis
Apoptosis is an evolutionarily conserved and tightly regulated cell death pathway.
Physiological cell death is important for maintaining homeostasis and optimal biological …
Physiological cell death is important for maintaining homeostasis and optimal biological …
[HTML][HTML] Regulation of Bim in health and disease
The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …
under both physiological and pathophysiological conditions. Tight regulation of its …
Whole genome association study of the plasma metabolome identifies metabolites linked to cardiometabolic disease in black individuals
Integrating genetic information with metabolomics has provided new insights into genes
affecting human metabolism. However, gene-metabolite integration has been primarily …
affecting human metabolism. However, gene-metabolite integration has been primarily …
Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK
X Liu, RR Chhipa, S Pooya… - Proceedings of the …, 2014 - National Acad Sciences
The multifunctional AMPK-activated protein kinase (AMPK) is an evolutionarily conserved
energy sensor that plays an important role in cell proliferation, growth, and survival. It …
energy sensor that plays an important role in cell proliferation, growth, and survival. It …
A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis
G Zadra, C Photopoulos, S Tyekucheva… - EMBO molecular …, 2014 - embopress.org
Abstract 5′ AMP‐activated kinase (AMPK) constitutes a hub for cellular metabolic and
growth control, thus representing an ideal therapeutic target for prostate cancers (PCas) …
growth control, thus representing an ideal therapeutic target for prostate cancers (PCas) …