Validated biomarkers to be used as biological tools for managing ocular surface diseases
(OSDs) are still an unmet need in daily clinical practice. Many studies have contributed to …

Over the years, multiple biomarkers have been used to aid in disease screening, diagnosis,
prognosis, and response to therapy. As of late, protein biomarkers are gaining strength in …

Purpose This study evaluated the presence and roles of cholesteryl esters (CEs) and wax
esters (WEs) from human tear film and meibum in meibomian gland dysfunction (MGD) …

Corneal architecture is essential for vision and is greatly perturbed by the absence of tears
due to the highly prevalent disorder dry eye. With no regenerative therapies available …

The glycosylation of proteins is one of the most common post-translational modifications
(PTMs) and plays important regulatory functions in diverse biological processes such as …

Autophagy is a catabolic self-degradative pathway that promotes the degradation and
recycling of intracellular material through the lysosomal compartment. Although first believed …

The cornea and covering tear film are together the 'objective lens' of the eye through which
80% of light is refracted. Despite exposure to a physically harsh and at times infectious or …

Purpose: The purpose of this study was to assess the safety, tolerability, dosing, and efficacy
of the active 19 amino acid fragment of lacritin (Lacripep), a broad regulator of ocular surface …

Dry eye disease (DED) is a common, multifactorial ocular disease impacting 5% to 20% of
people in Western countries and 45% to 70% in Asian countries. Despite the prevalence of …

The ocular surface has the challenging responsibility of maintaining a clear moist refractive
surface while protecting the eye from exogenous pathogens and the environment …