Down syndrome (DS) is a neurological disorder with multiple immune-related symptoms;
however, crosstalk between the CNS and peripheral immune system remains unexplored …

Persistent androgen receptor (AR) signalling is the main driver of prostate cancer (PCa).
Truncated isoforms of the AR called androgen receptor variants (AR-Vs) lacking the ligand …

Autophagy is a critical cellular process by which biomolecules and cellular organelles are
degraded in an orderly manner inside lysosomes. This process is particularly important in …

Neuronal loss is the central issue in Alzheimer's disease (AD), yet no treatment developed
so far can halt AD-associated neurodegeneration. Here, we developed a monoclonal …

Fetal stages are critical periods for brain development. However, the protein molecular
signature and dynamics of the human brain remain unclear due to sampling difficulty and …

Down syndrome (DS) is the most common chromosomal disorder and a major cause of
intellectual disability. The genetic etiology of DS is the extra copy of chromosome 21 …

Defective mitochondria are pathophysiological features of a number of neurodegenerative
diseases. Here, we investigated mitochondrial dysfunction in the context of the rare …

Methamphetamine (METH), a psychostimulant, has the potential to cause
neurodegeneration by targeting the cerebrum and cerebellum. It has been suggested that …

Docosahexaenoic acid (DHA) alleviates hepatic lipid accumulation in fish, but the
underlying mechanism remains unclear. Studies in mammals showed that promoting fatty …

Electrides in a two-dimensional (2D) scale, especially those that capture inherent
magnetism and have low work functions, have shown great application prospects in …