The crisis currently facing antibacterial chemotherapy threatens to return our treatment of
bacterial infections to the so-called 'dark age'of a preantibiotic era with the alarming …

Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …

The process of protein translation and, in particular, the macromolecular ribozyme that is the
ribosome were among the first recognized molecular targets for antibiotics. A great number …

Thiopeptides, or thiazolyl peptides, are a relatively new family of antibiotics that already
counts with more than one hundred different entities. Although they are mainly isolated from …

Several classes of clinically important antibiotics target the bacterial ribosome, where they
interfere with microbial protein synthesis. Structural studies of the interaction of antibiotics …

Thiostrepton and micrococcin inhibit protein synthesis by binding to the L11 binding domain
(L11BD) of 23S ribosomal RNA. The two compounds are structurally related, yet they …

The recent development of thiopeptide analogues of antibiotics has allowed some of the
limitations inherent to these naturally occurring substances to be overcome. Chemical …

Recently, we isolated a new thiopeptide antibiotic, TP-1161, from the fermentation broth of a
marine actinomycete typed as a member of the genus Nocardiopsis. Here we report the …

Targeting RNA with small molecule drugs is an area of great potential for therapeutic
treatment of infections and possibly genetic and autoimmune diseases. However, a mature …

Design, synthesis, and biological evaluation of several domains of the thiopeptide antibiotic
thiostrepton led to the discovery of a biologically active fragment. The biological properties of …