PEGylated therapeutics in the clinic

Y Gao, M Joshi, Z Zhao… - … & translational medicine, 2024 - Wiley Online Library
The covalent attachment of polyethylene glycol (PEG) to therapeutic agents, termed
PEGylation, is a well‐established and clinically proven drug delivery approach to improve …

Patient acceptability of intravitreal complement inhibitors in geographic atrophy (GA): protocol for a UK-based cross-sectional study

C Dinah, J Enoch, A Ghulakhszian, M Sekhon… - BMJ open, 2024 - bmjopen.bmj.com
Introduction Geographic atrophy (GA) is the advanced form of the non-neovascular ('dry')
type of age-related macular degeneration (AMD). Previously untreatable, complement …

Piloting a forced-choice task to elicit treatment preferences in geographic atrophy

J Enoch, A Ghulakhszian, M Sekhon, DP Crabb… - BMC Research …, 2023 - Springer
Abstract Objective Geographic Atrophy (GA) is the advanced form of the non-neovascular
('dry') type of age-related macular degeneration (AMD) and responsible for one-quarter of …

[HTML][HTML] Protocol: Patient acceptability of intravitreal complement inhibitors in geographic atrophy (GA): protocol for a UK-based cross-sectional study

C Dinah, J Enoch, A Ghulakhszian, M Sekhon… - BMJ Open, 2024 - ncbi.nlm.nih.gov
Introduction Geographic atrophy (GA) is the advanced form of the non-neovascular ('dry')
type of age-related macular degeneration (AMD). Previously untreatable, complement …

Association of sildenafil use with age-related macular degeneration: a retrospective cohort study

JED Han, A Subramanian, WH Lee… - BMJ Open …, 2024 - bmjophth.bmj.com
Objective Despite significant advances in clinical care and understanding of the underlying
pathophysiology, age-related macular degeneration (AMD)—a major cause of global …

Using the nominal group technique to priortise the burden of geographic atrophy and treatment expectations of therapies: perspectives from patient leaders

N Paudel, EM Moran, S Stafford, K McVicker… - 2024 - researchsquare.com
Background Age-related macular degeneration (AMD) is a leading cause of blindness
worldwide, affecting approximately 200 million people. Geographic atrophy (GA), an …

[HTML][HTML] Tools & Trackers

J List, GTA Head - statnews.com
T he eye is a complex and delicate organ. Traditionally, therapeutic innovations in this space
have been characterized by several challenges. For one, the physiological barrier between …