A 5′-flanking C/G pair at the core region enhances the recognition and binding of Kaiso to methylated DNA
Methyl CpG binding proteins (MBPs) are transcription factors that recognize the methylated
CpG sites in DNA and mediate the DNA methylation signal into various downstream cellular …
CpG sites in DNA and mediate the DNA methylation signal into various downstream cellular …
Probing the microscopic structure and flexibility of oxidized DNA by molecular simulations
The oxidative damage of DNA is a compelling issue in molecular biophysics as it plays a
vital role in the epigenetic control of gene expression and is believed to be associated with …
vital role in the epigenetic control of gene expression and is believed to be associated with …
Base flipping mechanism and binding strength of methyl-damaged DNA during the interaction with AGT
RP Koirala, NP Adhikari - Journal of Biological Physics, 2024 - Springer
Methyl damage to DNA bases is common in the cell nucleus. O6-alkylguanine-DNA alkyl
transferase (AGT) may be a promising candidate for direct damage reversal in methylated …
transferase (AGT) may be a promising candidate for direct damage reversal in methylated …
Unbinding of Alpha Chain of Hemoglobin in Sickle and Normal Structures
Sickle cell disease, a genetic disorder, is caused by a mutation of glutamic acid into valine in
the β chain of hemoglobin at the sixth residue, resulting in structural change of the entire …
the β chain of hemoglobin at the sixth residue, resulting in structural change of the entire …
Elastic property of sickle and normal hemoglobin protein: Molecular dynamics
J Powrel, NP Adhikari - AIP Advances, 2022 - pubs.aip.org
This work focuses on identifying the conformational stability and binding components in
sickle and normal hemoglobin to explore the elastic properties and realize the stiffness by …
sickle and normal hemoglobin to explore the elastic properties and realize the stiffness by …
Structural stability of R-state conformation of carbonmonoxyl sickle and normal hemoglobin dimer
A mutation at the sixth residue, glutamic acid to valine, in beta chain of hemoglobin distorts
the entire shape of hemoglobin into a sickle shape. The investigation of the binding …
the entire shape of hemoglobin into a sickle shape. The investigation of the binding …
Flipping Back of Extrahelical Guanine after Methyl Repair
RP Koirala, NP Adhikari - BIBECHANA, 2022 - nepjol.info
Methylation at O6 atom of guanine is a type of DNA damage which can cause a cancer. This
damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6 …
damage at O6 atom of guanine in a DNA can be transferred to SG atom of cysteine in O6 …