ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities

N Zamorano Cuervo, N Grandvaux - elife, 2020 - elifesciences.org
Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with …

The emerging role of ACE2 in physiology and disease

I Hamming, ME Cooper, BL Haagmans… - The Journal of …, 2007 - Wiley Online Library
The renin–angiotensin–aldosterone system (RAAS) is a key regulator of systemic blood
pressure and renal function and a key player in renal and cardiovascular disease. However …

Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II–dependent hypertension

J Wysocki, M Ye, E Rodriguez… - …, 2010 - Am Heart Assoc
Angiotensin (Ang)-converting enzyme 2 (ACE2) cleaves Ang II to form Ang-(1-7). Here we
examined whether soluble human recombinant ACE2 (rACE2) can efficiently lower Ang II …

[HTML][HTML] ACE and ACE2 in kidney disease

S Mizuiri, Y Ohashi - World journal of nephrology, 2015 - ncbi.nlm.nih.gov
Renin angiotensin system (RAS) activation has a significant influence on renal disease
progression. The classical angiotensin-converting enzyme (ACE)-angiotensin II (Ang II)-Ang …

Angiotensin‐converting enzyme 2: the first decade

NE Clarke, AJ Turner - International journal of hypertension, 2012 - Wiley Online Library
The renin‐angiotensin system (RAS) is a critical regulator of hypertension, primarily through
the actions of the vasoactive peptide Ang II, which is generated by the action of angiotensin …

ACE2 of the heart: from angiotensin I to angiotensin (1–7)

S Keidar, M Kaplan… - Cardiovascular …, 2007 - academic.oup.com
Abstract Angiotensin II (Ang II), a bioactive peptide of the renin–angiotensin system (RAAS),
plays an important role in the development of cardiovascular diseases (CVD) …

Physiology of kidney renin

H Castrop, K Höcherl, A Kurtz… - Physiological …, 2010 - journals.physiology.org
The protease renin is the key enzyme of the renin-angiotensin-aldosterone cascade, which
is relevant under both physiological and pathophysiological settings. The kidney is the only …

ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension

E Mendoza-Torres, A Oyarzún… - Therapeutic …, 2015 - journals.sagepub.com
The renin–angiotensin system (RAS) is a key component of cardiovascular physiology and
homeostasis due to its influence on the regulation of electrolyte balance, blood pressure …

Clinical characteristics of coronavirus disease 2019 (COVID-19) patients with hypertension on renin–angiotensin system inhibitors

X Zhou, J Zhu, T Xu - Clinical and experimental hypertension, 2020 - Taylor & Francis
ABSTRACT In December 2019, COVID-19 outbroke in Wuhan, China. The current study
aimed to explore the clinical characteristics of COVID-19 complicated by hypertension. In …

Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents

JA Hernández Prada, AJ Ferreira, MJ Katovich… - …, 2008 - Am Heart Assoc
Angiotensin-converting enzyme 2 (ACE2) is a key renin-angiotensin system enzyme
involved in balancing the adverse effects of angiotensin II on the cardiovascular system, and …