The mucosal secretory immune system provides an important primary defence against
disease, as studies of humans with mucosal humoral immunodeficiencies suggest that the …

The current challenge in influenza vaccine design is to induce long-lasting protection not
only against the vaccine strain, but also against drifted (point mutations in the surface …

Background: IgA serum autoantibodies against tissue transglutaminase (tTG) have an
established diagnostic value in coeliac disease, and high efficacy tests are widely available …

Acquired immunity to murine Chlamydia trachomatis genital tract reinfection has long been
assumed to be solely dependent on cell-mediated immunity. However, in this study, we …

Mucosally active subunit vaccines are an unmet clinical need due to lack of licensed
immunostimulants suitable for vaccine antigens. Here, we show that intranasal …

Wound healing is primarily controlled by the proliferation and migration of keratinocytes and
fibroblasts as well as the complex interactions between these two cell types. To investigate …

In this study pulmonary vaccination with a new influenza subunit vaccine powder was
evaluated. Vaccine powder was produced by spray-freeze drying (SFD) using the …

TGF-β receptor (TβR) signaling is important for systemic IgA production; however, its
contribution to IgA secretion at mucosal sites remained uncertain. This important question …

IgA is the predominant Ig isotype in mucosal tissue and is believed to be involved in defense
against viral and bacterial infections at these sites. Here, we examined the role of IgA in the …

Immunoglobulin A (IgA) is the most abundant Ig in mucosae where it plays key roles in host
defense against pathogens and in mucosal immunoregulation. Whereas intense research …