Psoriasis is a chronic inflammatory skin disease, the immunologic model of which has been
profoundly revised following recent advances in the understanding of its pathophysiology. In …

Highlights•Plaque psoriasis exhibits both autoimmune and autoinflammatory immune
responses.•The autoinflammatory loop in psoriasis is driven by IL-36 cytokine responses.• …

Psoriasis and coronary artery disease (CAD) are related comorbidities that are well
established, but whether a genetic basis underlies this is not well studied. We apply trans …

Psoriasis is defined as chronic, immune‐mediated disease. Regardless of the development
of new therapeutic approaches, the precise etiology of psoriasis remains unknown and …

Epidermal infiltration of neutrophils is a hallmark of psoriasis, where their activation leads to
release of neutrophil extracellular traps (NETs). The contribution of NETs to psoriasis …

Mucosal-associated invariant T (MAIT) cells use canonical semi-invariant T cell receptors
(TCR) to recognize microbial riboflavin precursors displayed by the antigen-presenting …

Psoriasis is a chronic inflammatory skin condition caused by a combination of hereditary and
environmental factors. Its development is closely related to the adaptive immune response. T …

Phospholipids comprise a large body of lipids that define cells and organelles by forming
membrane structures. Importantly, their complex metabolism represents a highly controlled …

Dyslipidemia refers to the abnormality of lipid metabolism. The aberrant lipid profiles are
usually characterized by elevated plasma levels of low-density lipoprotein cholesterol (LDL …

Persistent skin inflammation and impaired resolution are the main contributors to psoriasis
and associated cardiometabolic complications. Omega-3 polyunsaturated fatty acids …