Complex diseases often have distinct mechanisms spanning multiple tissues. We propose
tissue–gene fine-mapping (TGFM), which infers the posterior inclusion probability (PIP) for …

The pioneering work of Dr Lewis K. Dahl established a relationship between kidney, salt,
and high blood pressure (BP), which led to the major genetic-based experimental model of …

The utilization of yak milk is still in a primary stage, and the nutrition composition of yak
colostrum is not systematically characterized at present. In this study, the lipids, fatty acids …

Arterial hypertension has remained the world's leading cause of morbidity and mortality for
more than 20 years. While early Genome-Wide Association Studies raised the hypothesis …

近年来, 中国儿童青少年血压水平及高血压患病率呈增加趋势, 儿童青少年血压增高将导致靶
器官损伤并增加其成年期罹患心脑血管疾病的风险. 文章分析了目前中国儿童青少年高血压的 …

Objectives: Hypertension is a common condition worldwide; however, its underlying
mechanisms remain largely unknown. This study aimed to identify urinary peptides …

BACKGROUND Hypertension is a common condition worldwide, yet its underlying
mechanisms remain largely unknown. This study aims at identifying urinary peptides …

BACKGROUND: Renal denervation lowers blood pressure (BP) in patients with uncontrolled
hypertension. We conducted an unbiased genomic screen to identify genetic variants that …

高血压病是最常见的慢性心血管病, 市场上降压药物种类众多, 但不同个体相关的药物代谢基因
存在多态性, 导致疗效千差万别. CYP2C9 基因1075 A> C 位点和ADRB1 基因1165 G> C …

高血压是心脑血管病的首要危险因素. 服用降压药物是目前控制高血压的最主要的措施,
然而个体间药物疗效差异性大. 药物基因组学发现个体间相关基因位点分布存在多态性 …