Axonal energy metabolism, and the effects in aging and neurodegenerative diseases

S Yang, JH Park, HC Lu - Molecular neurodegeneration, 2023 - Springer
Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

[HTML][HTML] White matter damage and degeneration in traumatic brain injury

RC Armstrong, GM Sullivan, DP Perl, JD Rosarda… - Trends in …, 2024 - cell.com
Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often
leads to persistent symptoms, and the risk of poor patient outcomes increases with aging …

Sarm1-dependent axon degeneration: Nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities

HY McGuinness, W Gu, Y Shi, B Kobe… - The …, 2024 - journals.sagepub.com
Axons are an essential component of the nervous system, and axon degeneration is an
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …

NAD+, Axonal Maintenance, and Neurological Disease

AS Alexandris, VE Koliatsos - Antioxidants & Redox Signaling, 2023 - liebertpub.com
Significance: The remarkable geometry of the axon exposes it to unique challenges for
survival and maintenance. Axonal degeneration is a feature of peripheral neuropathies …

Application of P7C3 compounds to investigating and treating acute and chronic traumatic brain injury

PS Sridharan, E Miller, AA Pieper - Neurotherapeutics, 2023 - Elsevier
Traumatic brain injury (TBI) is a leading worldwide cause of disability, and there are
currently no medicines that prevent, reduce, or reverse acute or chronic neurodegeneration …

Traumatic axonopathy in spinal tracts after impact acceleration head injury: ultrastructural observations and evidence of SARM1-dependent axonal degeneration

AS Alexandris, Y Lee, M Lehar, Z Alam… - Experimental …, 2023 - Elsevier
Traumatic axonal injury (TAI) and the associated axonopathy are common consequences of
traumatic brain injury (TBI), contributing to significant neurological impairments following …

Autophagy protein ULK1 interacts with and regulates SARM1 during axonal injury

HMC Choi, Y Li, D Suraj, RC Hsia… - Proceedings of the …, 2022 - National Acad Sciences
Autophagy is a cellular catabolic pathway generally thought to be neuroprotective. However,
autophagy and in particular its upstream regulator, the ULK1 kinase, can also promote …

The therapeutic potential of berberine chloride against SARM1‐dependent axon degeneration in acrylamide‐induced neuropathy

S Wang, Y Zhang, J Lou, H Yong, S Shan… - Phytotherapy …, 2023 - Wiley Online Library
Chronic acrylamide (ACR) intoxication causes typical pathology of axon degeneration.
Moreover, sterile‐α and toll/interleukin 1 receptor motif‐containing protein 1 (SARM1), the …

Traumatic axonal injury in the optic nerve: the selective role of SARM1 in the evolution of distal axonopathy

AS Alexandris, Y Lee, M Lehar, Z Alam… - Journal of …, 2023 - liebertpub.com
Traumatic axonal injury (TAI), thought to be caused by rotational acceleration of the head, is
a prevalent neuropathology in traumatic brain injury (TBI). TAI in the optic nerve is a …

Mitophagy suppresses motor neuron necroptotic mitochondrial damage and alleviates necroptosis that converges to SARM1 in acrylamide‐induced dying‐back …

S Wang, Y Yang, Z Yu, M Song, Z Liu… - Journal of …, 2023 - Wiley Online Library
Acrylamide (ACR), a common industrial ingredient that is also found in many foodstuffs,
induces dying‐back neuropathy in humans and animals. However, the mechanisms remain …