The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …

High-grade gliomas in children are different from those that arise in adults. Recent
collaborative molecular analyses of these rare cancers have revealed previously …

Abstract Canonical (H3. 1/H3. 2) and noncanonical (H3. 3) histone 3 K27M-mutant gliomas
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …

Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily
in the midline of the central nervous system of young children, suggesting a cooperation …

Diffuse intrinsic pontine glioma (DIPG) and other diffuse midline gliomas (DMGs) with
mutated histone H3 K27M (H3-K27M),,,–are aggressive and universally fatal pediatric brain …

Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly
gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M …

Active neurons exert a mitogenic effect on normal neural precursor and oligodendroglial
precursor cells, the putative cellular origins of high-grade glioma (HGG). By using …

Introduction Myelin is formed by mature oligodendrocytes to facilitate fast propagation of
action potentials in axons. Small changes in myelin thickness can confer substantial …

Chemotherapy results in a frequent yet poorly understood syndrome of long-term
neurological deficits. Neural precursor cell dysfunction and white matter dysfunction are …

Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical
screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated …