Cancer metabolism and mitochondria: Finding novel mechanisms to fight tumours

S Missiroli, M Perrone, I Genovese, P Pinton… - EBioMedicine, 2020 - thelancet.com
Mitochondria are dynamic organelles that have essential metabolic activity and are
regarded as signalling hubs with biosynthetic, bioenergetics and signalling functions that …

Mitochondria targeting as an effective strategy for cancer therapy

P Ghosh, C Vidal, S Dey, L Zhang - International journal of molecular …, 2020 - mdpi.com
Mitochondria are well known for their role in ATP production and biosynthesis of
macromolecules. Importantly, increasing experimental evidence points to the roles of …

[HTML][HTML] Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes

D Milenkovic, J Misic, JF Hevler, T Molinié, I Chung… - Cell Metabolism, 2023 - cell.com
The mammalian respiratory chain complexes I, III 2, and IV (CI, CIII 2, and CIV) are critical for
cellular bioenergetics and form a stable assembly, the respirasome (CI-CIII 2-CIV), that is …

Regulation and functional role of the electron transport chain supercomplexes

S Cogliati, JL Cabrera-Alarcón… - Biochemical Society …, 2021 - portlandpress.com
Mitochondria are one of the most exhaustively investigated organelles in the cell and most
attention has been paid to the components of the mitochondrial electron transport chain …

Oxidative phosphorylation as a potential therapeutic target for cancer therapy

V Sica, JM Bravo‐San Pedro, G Stoll… - International journal of …, 2020 - Wiley Online Library
In contrast to prior belief, cancer cells require oxidative phosphorylation (OXPHOS) to strive,
and exacerbated OXPHOS dependency frequently characterizes cancer stem cells, as well …

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

LF Dong, J Kovarova, M Bajzikova, A Bezawork-Geleta… - elife, 2017 - elifesciences.org
Recently, we showed that generation of tumours in syngeneic mice by cells devoid of
mitochondrial (mt) DNA (ρ0 cells) is linked to the acquisition of the host mtDNA. However …

Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells

M Bajzikova, J Kovarova, AR Coelho, S Boukalova… - Cell metabolism, 2019 - cell.com
Cancer cells without mitochondrial DNA (mtDNA) do not form tumors unless they
reconstitute oxidative phosphorylation (OXPHOS) by mitochondria acquired from host …

Oncogenic pathways and the electron transport chain: a dangeROS liaison

V Raimondi, F Ciccarese, V Ciminale - British journal of cancer, 2020 - nature.com
Driver mutations in oncogenic pathways, rewiring of cellular metabolism and altered ROS
homoeostasis are intimately connected hallmarks of cancer. Electrons derived from different …

Mitocans revisited: mitochondrial targeting as efficient anti-cancer therapy

L Dong, V Gopalan, O Holland, J Neuzil - International journal of …, 2020 - mdpi.com
Mitochondria are essential cellular organelles, controlling multiple signalling pathways
critical for cell survival and cell death. Increasing evidence suggests that mitochondrial …

Targeting mitochondrial iron metabolism suppresses tumor growth and metastasis by inducing mitochondrial dysfunction and mitophagy

C Sandoval-Acuna, N Torrealba, V Tomkova… - Cancer Research, 2021 - AACR
Deferoxamine (DFO) represents a widely used iron chelator for the treatment of iron
overload. Here we describe the use of mitochondrially targeted deferoxamine (mitoDFO) as …