The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …

Macrophages facilitate essential homeostatic functions eg, endocytosis, phagocytosis, and
signaling during inflammation, and express a variety of scavenger receptors including …

The macrophage mannose receptor (MR, CD206) is a C-type lectin expressed
predominantly by most tissue macrophages, dendritic cells and specific lymphatic or …

In obesity, persistent low-grade inflammation is considered as a major contributor towards
the progression to insulin resistance and type 2 diabetes while in lean subjects the immune …

Immunostimulatory spherical nucleic acids (IS‐LSNAs) comprised of RNA selective for toll‐
like receptors (TLRs) 7/8 are synthesized and characterized. These structures consist of …

Biodegradable polymeric nanoparticles (NP) made from poly (lactid-co-glycolide) acid
(PLGA) and chitosan (CS) hold promise as innovative formulations for targeted delivery …

Lectins, defined as proteins that recognize carbohydrates, perform numerous essential
biological functions. Recognizing a diverse array of carbohydrate structures, vertebrate …

Abstract Synthetic oligodeoxyribonucleotides (ODNs) containing CpG (unmethylated
deoxycytidylyl-deoxyguanosine dinucleotide) motifs activate endosomal TLR9. The …

DNA and RNA, the nucleic acids found in every living organism, are quite crucial, because
not only do they store the genetic information, but also they are used as signals through …

cFLIP, an inhibitor of apoptosis, is a crucial regulator of cellular death by apoptosis and
necroptosis; its importance in development is exemplified by the embryonic lethality in cFLIP …