With the emergence of antibiotic resistance, the interest for antimicrobial agents has recently
increased again in public health. Copper was recognized in 2008 by the United States …

Transition metals occupy an essential niche in biological systems. Their electrostatic
properties stabilize substrates or reaction intermediates in the active sites of enzymes, and …

Zinc (Zn) and copper (Cu) are essential for optimal innate immune function, and nutritional
deficiency in either metal leads to increased susceptibility to bacterial infection. Recently, the …

Metals such as mercury, arsenic, copper and silver have been used in various forms as
antimicrobials for thousands of years with until recently, little understanding of their mode of …

Protein metal-coordination sites are richly varied and exquisitely attuned to their inorganic
partners, yet many metalloproteins still select the wrong metals when presented with …

Transition metal chemistry is essential to life, where metal binding to DNA, RNA, and
proteins underpins all facets of the central dogma of biology. In this context, metals in …

Copper (Cu) is an essential trace element for all aerobic organisms. It functions as a cofactor
in enzymes that catalyze a wide variety of redox reactions due to its ability to cycle between …

The transition or d-block metal ions manganese, iron, cobalt, nickel, copper, zinc and to a
more specialized degree molybdenum, tungsten, and vanadium have been shown to be …

Copper is an important micronutrient required as a redox co-factor in the catalytic centers of
enzymes. However, free copper is a potential hazard because of its high chemical reactivity …

The interplay of the presence of nickel and protein disorder in processes affecting human
health is the focus of the present review. Many systems involving nickel as either a cofactor …