The Pseudomonas aeruginosa LasB elastase (elastase B, pseudolysin) is the predominant
protease in the P. aeruginosa secretome. It has been shown to hydrolyse a vast array of host …

The beginning of the 1980s may well be remembered as a turning point in the treatment of
hypertension, one of the most common of man's afflictions.'In 1980 and 1981, the first …

FK228 is a histone deacetylase (HDAC) inhibitor, the molecular mechanismof inhibition of
which has been unknown. Here we show that reduction of an intramolecular disulfide bond …

Histone deacetylases (HDACs) are a family of enzymes involved in the regulation of gene
expression, DNA repair, and stress response. These processes often are altered in tumors …

Recent crystallographic and other studies havesuggested a detailed mechanism of action
for thermolysin, carboxypeptidase A, and related zinc endopeptidases. These studies also …

CaM binding protein discovered that actually has higher af-finity for CaM compared to CaM-
Ca2+„. We have avoided the temptation of naming P-57 more specifically until its function …

A uniform treatment of the four protease groups and a discussion of the differences and
similarities in their action is presented in this important new publication. Serine, cysteine …

An extracellular Zn-endopeptidase was purified to homogeneity from the culture filtrates of
Streptococcus faecalis (human oral strain 0G1–10) by a procedure that comprised …

A computer program for de novo molecular design was used to explore thediversity of
molecules complementary to the binding sites of enzymes. The program, GrowMol* 1 …

Revised Manuscript Received August 6, 1987 abstract: The modes of binding to thermolysin
of two phosphonamidate peptide inhibitors, carbobenz-oxy-G/y'-L-Leu-L-Leu (ZGPLL) and …