Inhibition of FGF‐FGFR and VEGF‐VEGFR signalling in cancer treatment

G Liu, T Chen, Z Ding, Y Wang, Y Wei, X Wei - Cell proliferation, 2021 - Wiley Online Library
The sites of targeted therapy are limited and need to be expanded. The FGF‐FGFR
signalling plays pivotal roles in the oncogenic process, and FGF/FGFR inhibitors are a …

FGFR a promising druggable target in cancer: Molecular biology and new drugs

R Porta, R Borea, A Coelho, S Khan, A Araújo… - Critical reviews in …, 2017 - Elsevier
Abstract Introduction The Fibroblast Growth Factor Receptor (FGFR) family consists of
Tyrosine Kinase Receptors (TKR) involved in several biological functions. Recently …

Signaling pathway and small-molecule drug discovery of FGFR: A comprehensive review

J Zheng, W Zhang, L Li, Y He, Y Wei, Y Dang… - Frontiers in …, 2022 - frontiersin.org
Targeted therapy is a groundbreaking innovation for cancer treatment. Among the receptor
tyrosine kinases, the fibroblast growth factor receptors (FGFRs) garnered substantial …

Design, synthesis, and insecticidal activities of novel 5‐substituted 4,5‐dihydropyrazolo[1,5‐a]quinazoline derivatives

S Yang, Q Lai, F Lai, X Jiang, C Zhao… - Pest Management …, 2021 - Wiley Online Library
BACKGROUND Chemical pesticides are the main measures for pest control, but have
caused growing resistance of pests and brought a series of environmental problems …

Cobalt nanoparticle adorned on boron-and nitrogen-doped 2D-carbon material for Sonogashira cross-coupling reactions: Greener and efficient synthesis of anti …

Z Khorsandi, AR Hajipour, MR Sarfjoo, RS Varma - Molecular Catalysis, 2022 - Elsevier
Herein, a novel heterogeneous cobalt catalyst was synthesized, characterized and its
efficiency in Sonogashira cross-coupling reaction was investigated. Nano cobalt species …

Molecular genomic features associated with in vitro response of the NCI‐60 cancer cell line panel to natural products

J Krushkal, S Negi, LM Yee, JR Evans… - Molecular …, 2021 - Wiley Online Library
Natural products remain a significant source of anticancer chemotherapeutics. The search
for targeted drugs for cancer treatment includes consideration of natural products, which …

CsF-mediated in situ desilylation of TMS-alkynes for Sonogashira reaction

JS Capani Jr, JE Cochran, J Liang - The Journal of Organic …, 2019 - ACS Publications
A practical and mild set of conditions for the Sonogashira reaction utilizing CsF-mediated in
situ TMS-alkyne desilylation followed by Sonogashira coupling has been developed for the …

Novel Class of Colony-Stimulating Factor 1 Receptor Kinase Inhibitors Based on an o-Aminopyridyl Alkynyl Scaffold as Potential Treatment for Inflammatory …

Z Xie, B Wu, Y Liu, W Ren, L Tong… - Journal of Medicinal …, 2020 - ACS Publications
Colony-stimulating factor 1 receptor (CSF-1R) is involved in inflammatory disorders as well
as in many types of cancer. Based on high-throughput screening and docking results, we …

2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: design, synthesis, in vitro cell-based …

AK El-Damasy, MM Haque, JW Park, SC Shin… - European Journal of …, 2020 - Elsevier
Prompted by the urgent demand for identification of new anticancer agents with improved
potency and efficacy, a new series of arylamides incorporating the privileged 2 …

Fused pyrrolo-pyridines and pyrrolo-(iso) quinoline<? index value=" pyrrolo-(iso) quinoline"?> as anticancer<? index value=" anticancer"?> agents

D Amariucai-Mantu, V Antoci, MC Sardaru… - Physical Sciences …, 2023 - degruyter.com
This work emphasizes the synthesis strategies and antiproliferative<? index value="
antiproliferative"?> related properties of fused pyrrolo-pyridine<? index value=" pyrrolo …