[HTML][HTML] A review of the recent development in the synthesis and biological evaluations of pyrazole derivatives
O Ebenezer, M Shapi, JA Tuszynski - Biomedicines, 2022 - mdpi.com
Pyrazoles are five-membered heterocyclic compounds that contain nitrogen. They are an
important class of compounds for drug development; thus, they have attracted much …
important class of compounds for drug development; thus, they have attracted much …
[HTML][HTML] Amino-pyrazoles in medicinal chemistry: A review
M Lusardi, A Spallarossa, C Brullo - International journal of molecular …, 2023 - mdpi.com
A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential.
Consequently, the search for new pyrazole-based compounds is of great interest to the …
Consequently, the search for new pyrazole-based compounds is of great interest to the …
Synthesis, structural, molecular docking and spectroscopic studies of (E)-N'-(4-methoxybenzylidene)-5-methyl-1H-pyrazole-3-carbohydrazide
Abstract (E)-N'-4-methoxybenzylidene-5-methyl-1H-pyrazole-3-carbohydrazide (E-MBPC)
has been synthesized and characterized by FT-IR, 1 H & 13 C NMR and ESI-MS …
has been synthesized and characterized by FT-IR, 1 H & 13 C NMR and ESI-MS …
[HTML][HTML] Heterocyclic compounds: pharmacology of pyrazole analogs from rational structural considerations
RF Costa, LC Turones, KVN Cavalcante… - Frontiers in …, 2021 - frontiersin.org
Low quality of life and life-threatening conditions often demand pharmacological screening
of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole …
of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole …
Design, synthesis and molecular docking of new pyrazole-thiazolidinones as potent anti-inflammatory and analgesic agents with TNF-α inhibitory activity
SS Abd El-Karim, HS Mohamed, MF Abdelhameed… - Bioorganic …, 2021 - Elsevier
A new set of derivatives bearing pyrazole-methylenehydrazono-thiazolidinone scaffold 4–23
was designed, synthesized and confirmed by different spectroscopic means and elemental …
was designed, synthesized and confirmed by different spectroscopic means and elemental …
Recent advancements in the development of heterocyclic anti-inflammatory agents
Most of the anti-inflammatory drugs in clinical practice are becoming outdated owing to their
potential side and adverse effects. These are found to be highly unsafe for long term use …
potential side and adverse effects. These are found to be highly unsafe for long term use …
In vitro and in silico studies of fluorinated 2, 3‐disubstituted thiazolidinone‐pyrazoles as potential α‐amylase inhibitors and antioxidant agents
As part of our effort to identify potent α‐amylase inhibitors, in the present study, a novel
series of fluorinated thiazolidinone‐pyrazole hybrid molecules were prepared by the …
series of fluorinated thiazolidinone‐pyrazole hybrid molecules were prepared by the …
[HTML][HTML] Design, synthesis, X-ray crystal structures, anticancer, DNA binding, and molecular modelling studies of pyrazole–pyrazoline hybrid derivatives
We have designed and synthesized three pyrazole analogs (4, 5a, 5b), pyrazole-based
chalcones (6a–6d) and (8a–8h), and N-formyl/acetyl 1, 3, 5-trisubstituted pyrazoline analogs …
chalcones (6a–6d) and (8a–8h), and N-formyl/acetyl 1, 3, 5-trisubstituted pyrazoline analogs …
The Fe3O4@ apple seed starch core-shell structure decorated In (III): A green biocatalyst for the one-pot multicomponent synthesis of pyrazole-fused isocoumarins …
In current decades, the fabrication and design of magnetic biocatalysts have been
advancing as green catalysts. Hence, in this paper, we use the apple seed starch to create …
advancing as green catalysts. Hence, in this paper, we use the apple seed starch to create …
Design, synthesis, molecular modelling and biological evaluation of novel 3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives as potent antioxidants and 15 …
Oxidative stress is one of the main causes of significant severe diseases. The discovery of
new potent antioxidants with high efficiency and low toxicity is a great demand in the field of …
new potent antioxidants with high efficiency and low toxicity is a great demand in the field of …