Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics
Few neuropsychiatric disorders have replicable biomarkers, prompting high-resolution and
large-scale molecular studies. However, we still lack consensus on a more foundational …
large-scale molecular studies. However, we still lack consensus on a more foundational …
Epigenetic age acceleration in frontotemporal lobar degeneration: a comprehensive analysis in the blood and brain
Frontotemporal lobar degeneration (FTLD) includes a heterogeneous group of disorders
pathologically characterized by the degeneration of the frontal and temporal lobes. In …
pathologically characterized by the degeneration of the frontal and temporal lobes. In …
Calculating detection limits and uncertainty of reference-based deconvolution of whole-blood DNA methylation data
DNA methylation (DNAm)-based cell mixture deconvolution (CMD) has become a
quintessential part of epigenome-wide association studies where DNAm is profiled in …
quintessential part of epigenome-wide association studies where DNAm is profiled in …
Quantifying the proportion of different cell types in the human cortex using DNA methylation profiles
E Hannon, EL Dempster, JP Davies, B Chioza… - BMC biology, 2024 - Springer
Background Due to interindividual variation in the cellular composition of the human cortex,
it is essential that covariates that capture these differences are included in epigenome-wide …
it is essential that covariates that capture these differences are included in epigenome-wide …
DNA methylation patterns in the frontal lobe white matter of multiple system atrophy, Parkinson's disease, and progressive supranuclear palsy: a cross-comparative …
M Murthy, K Fodder, Y Miki, N Rambarack… - Acta …, 2024 - Springer
Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized by
neuronal loss and gliosis, with oligodendroglial cytoplasmic inclusions (GCIs) containing α …
neuronal loss and gliosis, with oligodendroglial cytoplasmic inclusions (GCIs) containing α …
[HTML][HTML] Transcriptome-and DNA methylation-based cell-type deconvolutions produce similar estimates of differential gene expression and differential methylation
Background Changing cell-type proportions can confound studies of differential gene
expression or DNA methylation (DNAm) from peripheral blood mononuclear cells (PBMCs) …
expression or DNA methylation (DNAm) from peripheral blood mononuclear cells (PBMCs) …
Statistical and Computational Methods for High-Dimensional Genomics Data
Y Ma - 2023 - deepblue.lib.umich.edu
Advancements in transcriptomic technologies have enabled the measurement of gene
expression at single cell resolution and provided spatial localization information on tissues …
expression at single cell resolution and provided spatial localization information on tissues …