G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …

Class B1 G protein-coupled receptors (GPCRs) play important roles in human physiology
and disease pathology. Using cryo-electron microscopy (cryo-EM) and X-ray …

Abstract N 6-methyladenosine (m6A) is the most abundant internal mRNA nucleotide
modification in mammals, regulating critical aspects of cell physiology and differentiation …

Advances in structural biology have provided important mechanistic insights into signaling
by the transmembrane core of G-protein coupled receptors (GPCRs); however, much less is …

Rhodopsin is a prototypical G protein-coupled receptor (GPCR) critical for vertebrate vision.
Research on GPCR signaling states has been facilitated using llama-derived nanobodies …

Pigment production is a unique character of melanocytes. Numerous factors are linked with
melanin production, including genetics, ultraviolet radiation (UVR) and inflammation …

The metabolism of glucose and lipids is essential for energy production in the body, and
dysregulation of the metabolic pathways of these molecules is implicated in various acute …

Proteinase‐activated receptors (PARs) are a four‐member family of G protein‐coupled
receptors defined by their irreversible proteolytic mechanism of activation. PARs have …

G-protein coupled receptors (GPCRs) transduce a wide range of extracellular signals. They
are key players in the majority of biologic functions including vision, olfaction, chemotaxis …

Abstract The Pattern Of Invasion (POI) of tumor cells into adjacent normal tissues clinically
predicts postoperative tumor metastasis/recurrence of early oral squamous cell carcinoma …