XMAP215 is a microtubule nucleation factor that functions synergistically with the γ-tubulin ring complex
How microtubules (MTs) are generated in the cell is a major question in understanding how
the cytoskeleton is assembled. For several decades, γ-tubulin has been accepted as the …
the cytoskeleton is assembled. For several decades, γ-tubulin has been accepted as the …
[HTML][HTML] The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy
Determining how microtubules (MTs) are nucleated is essential for understanding how the
cytoskeleton assembles. While the MT nucleator, γ-tubulin ring complex (γ-TuRC) has been …
cytoskeleton assembles. While the MT nucleator, γ-tubulin ring complex (γ-TuRC) has been …
Human CLASP2 specifically regulates microtubule catastrophe and rescue
Cytoplasmic linker-associated proteins (CLASPs) are microtubule-associated proteins
essential for microtubule regulation in many cellular processes. However, the molecular …
essential for microtubule regulation in many cellular processes. However, the molecular …
Microtubule minus-end stability is dictated by the tubulin off-rate
Dynamic organization of microtubule minus ends is vital for the formation and maintenance
of acentrosomal microtubule arrays. In vitro, both microtubule ends switch between phases …
of acentrosomal microtubule arrays. In vitro, both microtubule ends switch between phases …
Synergistic stabilization of microtubules by BUB-1, HCP-1, and CLS-2 controls microtubule pausing and meiotic spindle assembly
During cell division, chromosome segregation is orchestrated by a microtubule-based
spindle. Interaction between spindle microtubules and kinetochores is central to the bi …
spindle. Interaction between spindle microtubules and kinetochores is central to the bi …
XMAP215 promotes microtubule catastrophe by disrupting the growing microtubule end
The GTP-tubulin cap is widely accepted to protect microtubules against catastrophe. The
GTP-cap size is thought to increase with the microtubule growth rate, presumably endowing …
GTP-cap size is thought to increase with the microtubule growth rate, presumably endowing …
[HTML][HTML] MTrack: automated detection, tracking, and analysis of dynamic microtubules
V Kapoor, WG Hirst, C Hentschel, S Preibisch… - Scientific reports, 2019 - nature.com
Microtubules are polar, dynamic filaments fundamental to many cellular processes. In vitro
reconstitution approaches with purified tubulin are essential to elucidate different aspects of …
reconstitution approaches with purified tubulin are essential to elucidate different aspects of …
Collective effects of XMAP215, EB1, CLASP2, and MCAK lead to robust microtubule treadmilling
Microtubule network remodeling is essential for fundamental cellular processes including
cell division, differentiation, and motility. Microtubules are active biological polymers whose …
cell division, differentiation, and motility. Microtubules are active biological polymers whose …
SSNA1 stabilizes dynamic microtubules and detects microtubule damage
Sjögren's Syndrome Nuclear Autoantigen 1 (SSNA1/NA14) is a microtubule-associated
protein with important functions in cilia, dividing cells and developing neurons. However, the …
protein with important functions in cilia, dividing cells and developing neurons. However, the …
The GTP-tubulin cap is not the determinant of microtubule end stability in cells
Microtubules are dynamic cytoskeletal polymers essential for cell division, motility, and
intracellular transport. Microtubule dynamics are characterized by dynamic instability—the …
intracellular transport. Microtubule dynamics are characterized by dynamic instability—the …