Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications

Z Sun, D Zhu, H Zhao, J Liu, P He, X Luan, H Hu… - Journal of …, 2023 - Springer
Functional hydrogels show potential application in repairing spinal cord injury (SCI) due to
their unique chemical, physical, and biological properties and functions. In this …

[HTML][HTML] Functional hydrogels as therapeutic tools for spinal cord injury: New perspectives on immunopharmacological interventions

CM Walsh, JK Wychowaniec, DF Brougham… - Pharmacology & …, 2022 - Elsevier
Spinal cord injury (SCI) is a complex medical and psychological challenge for which there is
no curative therapy currently available. Despite major progress in pharmacological and …

Restoration of spinal cord biophysical microenvironment for enhancing tissue repair by injury-responsive smart hydrogel

C Fan, W Yang, L Zhang, H Cai, Y Zhuang, Y Chen… - Biomaterials, 2022 - Elsevier
Spinal cord injury (SCI) represents a central nervous system disaster, resulting in the
destruction of spinal cord structure and function and the formation of an adverse …

Controlled delivery of a neurotransmitter–agonist conjugate for functional recovery after severe spinal cord injury

Y Zuo, J Ye, W Cai, B Guo, X Chen, L Lin, S Jin… - Nature …, 2023 - nature.com
Despite considerable unmet medical needs, effective pharmacological treatments that
promote functional recovery after spinal cord injury remain limited. Although multiple …

Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury

A Fang, Y Wang, N Guan, Y Zuo, L Lin, B Guo… - nature …, 2023 - nature.com
The transplantation of mesenchymal stem cells-derived secretome, particularly extracellular
vesicles is a promising therapy to suppress spinal cord injury-triggered neuroinflammation …

[HTML][HTML] Injectable hydrogels for spinal cord injury repair

H Wang, H Zhang, Z Xie, K Chen, M Ma, Y Huang… - Engineered …, 2022 - Elsevier
Spinal cord injury (SCI) often causes severe functional impairment of body, which leads to a
huge burden to the patient and the whole society. Many strategies, especially biomaterials …

Cell development enhanced bionic silk hydrogel on remodeling immune pathogenesis of spinal cord injury via m2 polarization of microglial

J Ling, T Huang, R Wu, C Ma, G Lin… - Advanced Functional …, 2023 - Wiley Online Library
Due to the complex spatial‐temporal pathophysiology of spinal cord injury (SCI), effective
modulation of SCI‐specific inflammatory pathogenesis to achieve desirable therapeutic …

An in vitro and ex vivo analysis of the potential of GelMA hydrogels as a therapeutic platform for preclinical spinal cord injury

CM Walsh, JK Wychowaniec, L Costello… - Advanced …, 2023 - Wiley Online Library
Spinal cord injury (SCI) is a devastating condition with no curative therapy currently
available. Immunomodulation can be applied as a therapeutic strategy to drive alternative …

Recent progress and challenges in the treatment of spinal cord injury

T Tian, S Zhang, M Yang - Protein & cell, 2023 - academic.oup.com
Spinal cord injury (SCI) disrupts the structural and functional connectivity between the higher
center and the spinal cord, resulting in severe motor, sensory, and autonomic dysfunction …

Microneedle/CD-MOF-mediated transdural controlled release of methylprednisolone sodium succinate after spinal cord injury

X Zhai, K Chen, X Wei, H Zhang, H Yang, K Jiao… - Journal of Controlled …, 2023 - Elsevier
A new method of transdural delivering drugs to the spinal cord has been developed,
involving the use of microneedles (MNs) and a β-cyclodextrin metal-organic framework (CD …