Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

D Hwang, JD Ramsey, AV Kabanov - Advanced drug delivery reviews, 2020 - Elsevier
Over the last three decades, polymeric micelles have emerged as a highly promising drug
delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules …

[HTML][HTML] Size, shape, charge and “stealthy” surface: Carrier properties affect the drug circulation time in vivo

J Di, X Gao, Y Du, H Zhang, J Gao, A Zheng - Asian journal of …, 2021 - Elsevier
The present review sets out to discuss recent developments of the effects and mechanisms
of carrier properties on their circulation time. For most drugs, sufficient in vivo circulation time …

Polymeric nanoparticles in gene therapy: New avenues of design and optimization for delivery applications

R Rai, S Alwani, I Badea - Polymers, 2019 - mdpi.com
The field of polymeric nanoparticles is quickly expanding and playing a pivotal role in a wide
spectrum of areas ranging from electronics, photonics, conducting materials, and sensors to …

Targeted delivery of drugs and genes using polymer nanocarriers for cancer therapy

W Xia, Z Tao, B Zhu, W Zhang, C Liu, S Chen… - International journal of …, 2021 - mdpi.com
Cancer is one of the primary causes of worldwide human deaths. Most cancer patients
receive chemotherapy and radiotherapy, but these treatments are usually only partially …

Listening to drug delivery and responses via photoacoustic imaging

B Park, S Park, J Kim, C Kim - Advanced Drug Delivery Reviews, 2022 - Elsevier
Administrating pharmaceutic agents efficiently to achieve the therapeutic effect is the aim of
all drug delivery techniques. Recent drug delivery systems aim to deliver high doses of …

Absorption, distribution, metabolism, and excretion of nanocarriers in vivo and their influences

A Zhang, K Meng, Y Liu, Y Pan, W Qu, D Chen… - Advances in Colloid and …, 2020 - Elsevier
As one of the most promising and effective delivery systems for targeted controlled-release
drugs, nanocarriers (NCs) have been widely studied. Although the development of …

Effects of nanoparticle size, shape, and zeta potential on drug delivery

K Öztürk, M Kaplan, S Çalış - International Journal of Pharmaceutics, 2024 - Elsevier
Nanotechnology has brought about a significant revolution in drug delivery, and research in
this domain is increasingly focusing on understanding the role of nanoparticle (NP) …

APTES monolayer coverage on self-assembled magnetic nanospheres for controlled release of anticancer drug Nintedanib

VC Karade, A Sharma, RP Dhavale, RP Dhavale… - Scientific Reports, 2021 - nature.com
The use of an appropriate delivery system capable of protecting, translocating, and
selectively releasing therapeutic moieties to desired sites can promote the efficacy of an …

Gain an advantage from both sides: Smart size-shrinkable drug delivery nanosystems for high accumulation and deep penetration

S Bai, Y Zhang, D Li, X Shi, G Lin, G Liu - Nano Today, 2021 - Elsevier
The first generation of nanomedicine exhibits superior performance in the clinical treatment
of various cancers compared to free conventional anticancer therapeutics. However, poor …

Microfluidics for producing poly (lactic-co-glycolic acid)-based pharmaceutical nanoparticles

X Li, X Jiang - Advanced drug delivery reviews, 2018 - Elsevier
Microfluidic chips allow the rapid production of a library of nanoparticles (NPs) with distinct
properties by changing the precursors and the flow rates, significantly decreasing the time …