C–H deuteration of organic compounds and potential drug candidates
C–H deuteration has been intricately developed to satisfy the urgent need for site-selectively
deuterated organic frameworks. Deuteration has been primarily used to study kinetic isotope …
deuterated organic frameworks. Deuteration has been primarily used to study kinetic isotope …
Therapeutic uses of bacterial subunit toxins
C Lingwood - Toxins, 2021 - mdpi.com
The B subunit pentamer verotoxin (VT aka Shiga toxin-Stx) binding to its cellular
glycosphingolipid (GSL) receptor, globotriaosyl ceramide (Gb3) mediates internalization and …
glycosphingolipid (GSL) receptor, globotriaosyl ceramide (Gb3) mediates internalization and …
Fluorophore position of headgroup-labeled Gb3 glycosphingolipids in lipid bilayers
Fluorescent lipid probes are an invaluable tool for investigating lipid membranes. In
particular, localizing certain receptor lipids such as glycosphingolipids within phase …
particular, localizing certain receptor lipids such as glycosphingolipids within phase …
Optical Manipulation of Gb3 Enriched Lipid Domains: Impact of Isomerization on Gb3‐Shiga Toxin B Interaction
L Socrier, S Ahadi, M Bosse, C Montag… - … A European Journal, 2023 - Wiley Online Library
The plasma membrane is a complex assembly of proteins and lipids that can self‐assemble
in submicroscopic domains commonly termed “lipid rafts”, which are implicated in …
in submicroscopic domains commonly termed “lipid rafts”, which are implicated in …
Single-mutations at the galactose-binding site of enzymes GalK, GalU, and LgtC enable the efficient synthesis of UDP-6-azido-6-deoxy-d-galactose and azido …
ME Ortiz-Soto, M Baier, D Brenner, M Timm… - …, 2023 - academic.oup.com
Lysosomal accumulation of the glycosphingolipid globotriaosylceramide Gb3 is linked to the
deficient activity of the α-galactosidase A in the Anderson–Fabry disease and an elevated …
deficient activity of the α-galactosidase A in the Anderson–Fabry disease and an elevated …
The Interaction of Gb3 Glycosphingolipids with ld and lo Phase Lipids in Lipid Monolayers Is a Function of Their Fatty Acids
L Socrier, C Bail, E Ackermann, AK Beresowski… - Langmuir, 2022 - ACS Publications
The glycosphingolipid Gb3 is a specific receptor of the bacterial Shiga toxin (STx). Binding of
STx to Gb3 is a prerequisite for its internalization into the host cells, and the ceramide's fatty …
STx to Gb3 is a prerequisite for its internalization into the host cells, and the ceramide's fatty …
Multicomponent lipid membranes—how molecular organisation leads to function
From 2009 to 2020, a group of scientists, with great expertise in the area of membrane
biophysics, closely worked together in the Collaborative Research Centre 803 (CRC 803 …
biophysics, closely worked together in the Collaborative Research Centre 803 (CRC 803 …
Synthesis of a Deuterium-Labeled Globotriaosylceramide Probe for Potential Imaging of Subcellular Localization of Gb3 Using NanoSIMS
MRE Aly, IHE Azab - Russian Journal of Organic Chemistry, 2021 - Springer
Globotriaosylceramide (Gb3) is a cell membrane glycosphingolipid expressed by renal cells
and gastrointestinal tract and overexpressed by many carcinomas. Subcellular distribution of …
and gastrointestinal tract and overexpressed by many carcinomas. Subcellular distribution of …