BACKGROUND Spermatozoa acquire their motility and fertilizing abilities during their
maturation through the epididymis. This process is controlled by epididymal epithelial cells …

The epididymis is a tubular structure connecting the vas deferens to the testis. This organ
consists of three main regions—caput, corpus, and cauda—that face opposing …

Macrophages are the principal immune cells of the epididymis and testis, but their origins,
heterogeneity, development, and maintenance are not well understood. Here, we describe …

Regulatory T cells (Tregs) modulate tissue homeostatic processes and immune responses.
Understanding tissue-Treg biology will contribute to developing precision-targeting …

The murine epididymis has 10 distinct segments that provide the opportunity to identify
compartmentalized cell physiological mechanisms underlying sperm maturation. However …

The epididymis functions as transition zone for post-testicular sperm maturation and storage
and faces contrasting immunological challenges, ie tolerance towards spermatozoa vs …

Introduction One of the most intriguing aspects of male reproductive physiology is the ability
of the epididymis to prevent the mounting of immune responses against the onslaught of …

Infection and inflammation of the male reproductive tract are relevant causes of infertility.
Inflammatory damage occurs in the special immunosuppressive microenvironment of the …

Mononuclear phagocytes (MPs) play an active role in the immunological homeostasis of the
urogenital tract. In the epididymis, a finely tuned balance between tolerance to antigenic …

Ascending bacterial urinary tract infections can cause epididymo-orchitis. In the cauda
epididymidis, this frequently leads to persistent tissue damage. Less coherent data is …