Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …

Genome-wide studies have revealed that mammalian genomes are pervasively transcribed.
This has led to the identification and isolation of novel classes of non-coding RNAs …

Resolving the spatial distribution of RNA and protein in tissues at subcellular resolution is a
challenge in the field of spatial biology. We describe spatial molecular imaging, a system …

We describe the identification and characterization of circular intronic long noncoding RNAs
in human cells, which accumulate owing to a failure in debranching. The formation of such …

Circular RNA (circRNA) is a large group of RNA family extensively existed in cells and
tissues. High-throughput sequencing provides a way to view circRNAs across different …

An inducible program of inflammatory gene expression is central to antimicrobial defenses.
This response is controlled by a collaboration involving signal-dependent activation of …

HeLa is the most widely used model cell line for studying human cellular and molecular
biology. To date, no genomic reference for this cell line has been released, and experiments …

Recent RNA sequencing studies have revealed that most of the human genome is
transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long …

The MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) locus is
misregulated in many human cancers and produces an abundant long nuclear-retained …

Since the introduction of the central dogma of molecular biology in 1958, various RNA
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …